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1.3.1.85: crotonyl-CoA carboxylase/reductase

This is an abbreviated version!
For detailed information about crotonyl-CoA carboxylase/reductase, go to the full flat file.

Word Map on EC 1.3.1.85

Reaction

(2S)-ethylmalonyl-CoA
+
NADP+
=
(E)-but-2-enoyl-CoA
+
CO2
+
NADPH
+
H+

Synonyms

2-octenoyl-CoA carboxylase/reductase, AntE, CCR, CCR1, CCRC, crotonyl-CoA carboxylase/reductase, crotonyl-CoA reductase (carboxylating), crotonyl-CoA reductase-carboxylase, ECR, enoyl-CoA carboxylase/reductase, pteB, rimJ

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.85 crotonyl-CoA carboxylase/reductase

Expression

Expression on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate
TetR-type activator CcrR regulates the expression of crotonyl-CoA reductase/carboxylase. A ccrR null mutant strain ismpaired in its ability to grow on C1 and C2 compounds, correlating with the reduced activity of crotonyl-CoA reductase/carboxylase. The activity of the promoter required for ccr expression decreases as much as 50% in the absence of ccrR compared to wild-type. CcrR directly binds to the region upstream of the katA-ccr promoter