1.3.1.76: precorrin-2 dehydrogenase

This is an abbreviated version!
For detailed information about precorrin-2 dehydrogenase, go to the full flat file.

Reaction

Synonyms

cobaltochelatase, CysG, CysG enzyme, cysG gene product, CysG2, EC 2.1.1.107, Met8p, P2D, precorrin-2 dehydrogenase, S-adenosyl-L-methionine(SAM)-dependent bismethyltransferase, dehydrogenase and ferrochelatase, SirC, siroheme synthase, siroheme synthetase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.76 precorrin-2 dehydrogenase

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Results	in table
20904	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
5	Cofactor
4	Crystallization (Commentary)
1	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
15	Organism
11	Pathway
24	PDB ID
1	Posttranslational Modification
12	Protein Variants
7	Purification (Commentary)
2	Reaction
3	Reaction Type
14	Reference
7	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
8	Subunits
31	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.3.1.76 - precorrin-2 dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

precorrin-2:NAD+ oxidoreductase

This enzyme catalyses the second of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction.