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1.3.1.70: DELTA14-sterol reductase

This is an abbreviated version!
For detailed information about DELTA14-sterol reductase, go to the full flat file.

Word Map on EC 1.3.1.70

Reaction

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol
+
NADP+
=
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
+
NADPH
+
H+

Synonyms

14-dehydrocholesterol reductase, 14-reductase, 14-SR, 3 beta-hydroxysterol-DELTA14-reductase, 3beta-hydroxysterol DELTA14-reductase, C-14 reductase, C-14 sterol reductase, C14-SR, C14-sterol reductase, C14SR, DELTA14-reductase, DELTA14-SR, DELTA14SR, DELTA7,14-steroid 14-reductase, DELTA7,14-sterol 14-reductase, DELTA7,14-sterol DELTA14-reductase, DELTA7,14-sterol-14-reductase, DELTA8,14-hydroxy steroid DELTA14(15)-reductase, DELTA8,14-steroid 14-reductase, DELTA8,14-sterol 14-reductase, DELTA8,14-sterol DELTA14-reductase, DELTA8,14-sterol-14-reductase, DHCR14, ERG 24, ERG24, erg24-1, erg24A, erg24B, fackel, FACKEL protein, FgERG24A, FgERG24B, FK, fk-J3158, integral membrane sterol reductase, lamin B receptor, lamin-B receptor, LBR, MaSR1, reductase, DELTA8,14-hydroxy steroid DELTA14(15)-, SR-1, sterol 14-reductase, sterol C-14 reductase, sterol C14-reductase, sterol DELTA14,15-reductase, sterol DELTA14-reductase, TM7SF2

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.70 DELTA14-sterol reductase

Substrates Products

Substrates Products on EC 1.3.1.70 - DELTA14-sterol reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
show the reaction diagram
4,4-dimethyl-5alpha-cholesta-8,12,24-trien-3beta-ol + NADPH + H+
4,4-dimethylzymosterol + NADP+
show the reaction diagram
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
show the reaction diagram
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
show the reaction diagram
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
show the reaction diagram
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
show the reaction diagram
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
show the reaction diagram
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
show the reaction diagram
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
show the reaction diagram
5alpha-cholesta-7,14-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
show the reaction diagram
-
43% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
show the reaction diagram
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
show the reaction diagram
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH
5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
show the reaction diagram
cholesta-8,14-dien-3beta-ol + NADPH
cholesta-8-en-3beta-ol + NADP+
show the reaction diagram
dihydro-follicular fluid meiosis-activating sterol + NADPH + H+
dihydro-testis meiosis-activating sterol + NADP+
show the reaction diagram
-
-
-
?
ergosta-8,14-dien-3beta-ol + NADPH
ergosta-8-en-3beta-ol + NADP+
show the reaction diagram
-
DELTA8,14-sterol, ignosterol
-
-
?
follicular fluid meiosis-activating sterol + NADPH
testicular meiosis-activating sterol + NADP+
show the reaction diagram
-
-
-
-
?
follicular fluid meiosis-activating sterol + NADPH + H+
testis meiosis-activating sterol + NADP+
show the reaction diagram
-
-
-
?
isofucosterol + NADPH
sitosterol + NADP+
show the reaction diagram
additional information
?
-