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15-aza-24-methylene-D-homocholestadiene-3beta-ol
2-amino-nonyl-6-methoxyl-tetralin muriate
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25-hydroxy-cholesterol
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IC50: 0.45 mM
3beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
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U18666A, IC50: 0.004 mM
4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
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using a genetic aproach in Saccharomyces cerevisiae it is shown that ERG24 is the target enzyme of compound 4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
A25822B
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competitive inhibitor
AY9944-A-7
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enzyme-specific inhibitor, leads to apoptosis in vivo at high concentrations in cumulus cells of oocytes
brefeldin
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inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cerulenin
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inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cholesterol
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enzyme suppressed by feeding 5% cholesterol, 70% decrease in enzyme activity
clotrimazole
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inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
Detergents
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enzyme solubilization by detergents: inactivation
fluconazole
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inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview
fluphenazine
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inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
HgCl2
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3 mM: more than 99% inhibition, inhibition negligible in the presence of 10 mM glutathione
itraconazole
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inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview
ketoconazole
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inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
miconazole
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IC50: 0.15 mM
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol
N-alkyl morpholine derivatives
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fungicides
N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
N-ethylmaleimide
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5 mM: 53% inhibition, inhibition negligible in the presence of 10 mM glutathione
N-substituted 8-azadecalins
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potent inhibitors
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
NADP+
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in the absence of NADPH-regenerating system, Ki: 0.45 mM; no inhibition by NAD+
Nystatin
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inhibition of growth of wild-type and mutant strain NJ25, not of mutants strains NJ50, NJ51, and NJ55, overview
Phospholipase A2
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very high inhibition by very small concentrations, activity not restored by addition of phospholipids or any components presumed to be released from treated microsomes. Various concentration ranges of potential cofactors including FMN, FAD, AMP, ADP, ATP, coenzyme Q, Coenzyme A, and hemin, plus heat-treated microsomes, and lipid extracts of microsomes does not restore microsomal 14-reductase of phospholipase A2-treated microsomes
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sulfhydryl-binding agents
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terbinafine
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inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
Triparanol
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4-chloro-alpha-[4-[2-diethylaminoethoxy]phenyl]-alpha-(4-methylphenyl)benze-methanol, slight inhibition
Tris-HCl
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Tris-HCl buffer, 28% inhibition, not restored by addition of KCl at various concentrations
Tween 80
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concentrations of Tween 80 higher than 1.5 g/l: inhibitory effect
15-aza-24-methylene-D-homocholestadiene-3beta-ol
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A25822B, extremely potent inhibitor
15-aza-24-methylene-D-homocholestadiene-3beta-ol
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A25822B, extremely potent inhibitor
15-azasterol
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antimycotic agent, IC50: 0.00003 mM
15-azasterol
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15-aza-24-methylene-D-homocholestadiene; potent antimycotic agent, designated A258223, non-competitively inhibition at very low concentrations, Ki: 0.000002 mM
15-azasterol
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antimycotic agent, IC50: 0.00003 mM
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
Ca2+
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slight inhibition of growth of the wild-type strain, increased inhibition of growth of erg24 mutant strains
Ca2+
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4 mM: very slight, 3.5% inhibition
cyanide
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no inhibition
cyanide
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cyanide ion, membrane-bound enzyme, modest inhibition at high concentrations, greater than 1 mM, partial purified enzyme, sodium cyanide, no or very poor inhibition, 10 mM: 3.5% inhibition
cycloheximide
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inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cycloheximide
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the 2.5fold increase in enzymic activity due to the diurnal rhythm is completely abolished by cycloheximide
fenpropidin
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fenpropidin
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fungicide, very potent inhibitor; IC50: 0.0018 mM; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-piperidine
fenpropidin
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fungicide, very potent inhibitor; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-piperidine
fenpropidin
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good inhibitor, IC50: 0.003 mM
fenpropimorph
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impairs cell expansion and affects gene expression in vivo, the effects cannot be reversed by addition of exogenous brassicasterols, changes sterol composition, phenotype is similar to fk-mutant plants, molecular mechanism
fenpropimorph
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inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
fenpropimorph
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fungicide, very potent inhibitor; IC50: 0.0023 mM; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine
fenpropimorph
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fungicide, very potent inhibitor; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine
fenpropimorph
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very good inhibitor, IC50: 0.0008 mM
Mg2+
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4 mM: slight, 6% inhibition
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol
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extremely potent inhibitor
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol
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extremely potent inhibitor
N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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strong inhibition
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N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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strong inhibition
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N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
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extremely potent inhibitor
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
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AY-9944, strong inhibition, 0.0003 mM: 50% inhibition, 0.0005 mM: 65% inhibition
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
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0.01% AY-9944: suppression and inhibition; AY-9944, competitive inhibitor, strong inhibition, Ki: 0.00026; AY-9944, direct inhibitory effects of sterol 14-reductase; hepatocyte, IC50: 0.00025 mM, microsomes, IC50: 0.0003 mM
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
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AY 9944, very slight inhibition, IC50: 0.04 mM
tridemorph
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inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
tridemorph
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2,6-dimethyl-N-tridecylmorpholine; fungicide; slight inhibitor, IC50: 0.098 mM
tridemorph
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2,6-dimethyl-N-tridecylmorpholine; fungicide
tridemorph
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slight inhibition, IC50: 0.025
additional information
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inhibition by a series of ammonium-ion-containing fungicides
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additional information
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no direct inhibition by 3beta-hydroxy-4,4-dimethyl-5alpha-cholest-8(14)-en-15-one, even when concentration is increased to level of Km for substrate; no inhibition by trypsin
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additional information
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kinetic pattern of inhibition; no inhibition by lovastatin, mevalonolactone, Squalestatin 1, (E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-((3,3'-bithiophen-5-yl)methoxy)benzenemethanamine, NB-598
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additional information
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no inhibition by ergosterol, up to 0.2 mM
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additional information
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inhibition by a series of ammonium-ion-containing fungicides; no inhibition by 4alpha,10-dimethyl-trans-decal-3beta-ol; no inhibition by menadione or 10 mM NAD+
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