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1.3.1.70: DELTA14-sterol reductase

This is an abbreviated version!
For detailed information about DELTA14-sterol reductase, go to the full flat file.

Word Map on EC 1.3.1.70

Reaction

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol
+
NADP+
=
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
+
NADPH
+
H+

Synonyms

14-dehydrocholesterol reductase, 14-reductase, 14-SR, 3 beta-hydroxysterol-DELTA14-reductase, 3beta-hydroxysterol DELTA14-reductase, C-14 reductase, C-14 sterol reductase, C14-SR, C14-sterol reductase, C14SR, DELTA14-reductase, DELTA14-SR, DELTA14SR, DELTA7,14-steroid 14-reductase, DELTA7,14-sterol 14-reductase, DELTA7,14-sterol DELTA14-reductase, DELTA7,14-sterol-14-reductase, DELTA8,14-hydroxy steroid DELTA14(15)-reductase, DELTA8,14-steroid 14-reductase, DELTA8,14-sterol 14-reductase, DELTA8,14-sterol DELTA14-reductase, DELTA8,14-sterol-14-reductase, DHCR14, ERG 24, ERG24, erg24-1, erg24A, erg24B, fackel, FACKEL protein, FgERG24A, FgERG24B, FK, fk-J3158, integral membrane sterol reductase, lamin B receptor, lamin-B receptor, LBR, MaSR1, reductase, DELTA8,14-hydroxy steroid DELTA14(15)-, SR-1, sterol 14-reductase, sterol C-14 reductase, sterol C14-reductase, sterol DELTA14,15-reductase, sterol DELTA14-reductase, TM7SF2

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.70 DELTA14-sterol reductase

Inhibitors

Inhibitors on EC 1.3.1.70 - DELTA14-sterol reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
15-aza-24-methylene-D-homocholestadiene-3beta-ol
15-azasterol
2-amino-nonyl-6-methoxyl-tetralin muriate
-
-
25-hydroxy-cholesterol
-
IC50: 0.45 mM
3beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
-
U18666A, IC50: 0.004 mM
4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
-
using a genetic aproach in Saccharomyces cerevisiae it is shown that ERG24 is the target enzyme of compound 4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
A25822B
-
competitive inhibitor
amorolfine
-
-
AY9944-A-7
-
enzyme-specific inhibitor, leads to apoptosis in vivo at high concentrations in cumulus cells of oocytes
brefeldin
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cerulenin
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cholesterol
-
enzyme suppressed by feeding 5% cholesterol, 70% decrease in enzyme activity
clotrimazole
-
inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
cyanide
cycloheximide
Detergents
-
enzyme solubilization by detergents: inactivation
fenpropidin
fenpropimorph
fluconazole
-
inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview
fluphenazine
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
HgCl2
-
3 mM: more than 99% inhibition, inhibition negligible in the presence of 10 mM glutathione
itraconazole
-
inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview
ketoconazole
-
inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
miconazole
-
IC50: 0.15 mM
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol
N-alkyl morpholine derivatives
-
fungicides
N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
N-ethylmaleimide
-
5 mM: 53% inhibition, inhibition negligible in the presence of 10 mM glutathione
N-substituted 8-azadecalins
-
potent inhibitors
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
NADP+
-
in the absence of NADPH-regenerating system, Ki: 0.45 mM; no inhibition by NAD+
Nystatin
-
inhibition of growth of wild-type and mutant strain NJ25, not of mutants strains NJ50, NJ51, and NJ55, overview
O2
-
28% inhibition
Phospholipase A2
-
very high inhibition by very small concentrations, activity not restored by addition of phospholipids or any components presumed to be released from treated microsomes. Various concentration ranges of potential cofactors including FMN, FAD, AMP, ADP, ATP, coenzyme Q, Coenzyme A, and hemin, plus heat-treated microsomes, and lipid extracts of microsomes does not restore microsomal 14-reductase of phospholipase A2-treated microsomes
-
spiroxamine
-
-
sulfhydryl-binding agents
-
-
-
terbinafine
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
tridemorph
Triparanol
-
4-chloro-alpha-[4-[2-diethylaminoethoxy]phenyl]-alpha-(4-methylphenyl)benze-methanol, slight inhibition
Tris-HCl
-
Tris-HCl buffer, 28% inhibition, not restored by addition of KCl at various concentrations
Triton X-100
-
-
Tween 80
-
concentrations of Tween 80 higher than 1.5 g/l: inhibitory effect
additional information
-