1.3.1.6: fumarate reductase (NADH)

This is an abbreviated version!
For detailed information about fumarate reductase (NADH), go to the full flat file.

Word Map on EC 1.3.1.6

1.3.1.6

nitrate

malate

shewanella

fad

flavoproteins

fumarase

iron-sulfur

succinogenes

ascaris

flavocytochrome

helminth

oneidensis

wolinella

viologen

anthelmintic

frigidimarina

succinate-ubiquinone

tetraheme

menaquinol

narghji

thiabendazole

sdhcdab

c4-dicarboxylate

geobacter

flavinylation

succinate:quinone

dmsabc

hymenolepis

cyma

putrefaciens

medicine

drug development

Reaction

Synonyms

ABB37_00293, FRD, FRdABCD, FRDg, FRDm1, FRDm2, FRDS, Frds1p, fumarate reductase, KPA86010, KPK_2907, mitochondrial rhodoquinol-fumarate reductase, NADH-dependent fumarate reductase, NADH-FR, NADH-FRD, NADH-fumarate reductase, NFRD, QFR

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.6 fumarate reductase (NADH)

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Results	in table
8	Activating Compound
846	AA Sequence
8	Application
1	CAS Registry Number
10	Cloned(Commentary)
68	Cofactor
3	Crystallization (Commentary)
57	Disease/ Diagnostics
2	Expression
11	General Information
2	General Stability
23	IC50 Value
86	Inhibitors
9	Ki Value [mM]
25	KM Value [mM]
34	Localization
6	Metals/Ions
3	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
77	Organism
2	Oxidation Stability
3	Pathway
4	PDB ID
10	pH Optimum
4	pH Range
1	pI Value
1	Posttranslational Modification
8	Protein Variants
12	Purification (Commentary)
2	Reaction
5	Reaction Type
67	Reference
26	Source Tissue
19	Specific Activity [micromol/min/mg]
2	Storage Stability
79	Substrates and Products (Substrate)
6	Subunits
60	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
24	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.3.1.6 - fumarate reductase (NADH)

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0.071

1-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-5-ol

Echinococcus multilocularis

in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C

684492

0.0011

decursin

Ascaris suum

689694

0.0048

decursinol

Ascaris suum

689694

0.0027

decursinol angelate

Ascaris suum

689694

0.000081

flutolanil

Ascaris suum

promising lead compound for anthelminthics

695392

0.016

N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide

Echinococcus multilocularis

in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C

684492

0.91

N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine

Echinococcus multilocularis

in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C

684492

0.048 - 4.1

N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine

2 entries

0.0023

N-[2-(4-tert-butylphenyl)ethyl]phthalazin-1-amine

Echinococcus multilocularis

in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C

684492

0.062

N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,6-diamine

Echinococcus multilocularis

in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C

684492

0.0021

N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,7-diamine

Echinococcus multilocularis

in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C

684492

0.0005

pyrvinium pamoate

2 entries

0.0000024

ukulactone A

2 entries

0.00047

ukulactone B

2 entries

0.000062

ukulactone C

Ascaris suum

pH and temperature not specified in the publication

740822

0.00085

wortmannilactone I

Ascaris suum

pH and temperature not specified in the publication

740157

0.00084

wortmannilactone J

Ascaris suum

pH and temperature not specified in the publication

740157

0.00135

wortmannilactone K

Ascaris suum

pH and temperature not specified in the publication

740157

0.00084

wortmannilactone L

Ascaris suum

pH and temperature not specified in the publication

740157