1.3.1.46: biochanin-A reductase
This is an abbreviated version!
For detailed information about biochanin-A reductase, go to the full flat file.
Reaction
Synonyms
reductase, biochanin A
ECTree
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Substrates Products on EC 1.3.1.46 - biochanin-A reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,7,3'-trihydroxy-4'-methoxyisoflavone + NADPH + H+
2-dihydropratensein + NADP+
-
trivial name pratensein, 78% of activity with biochanin A
-
?
5,7,3'-trihydroxyisoflavone + NADPH + H+
2-dihydrogenistein + NADP+
-
trivial name genistein, 44% of activity with biochanin A
-
?
6,7-dihydroxy-4'-methoxyisoflavone + NADPH + H+
(3S)-2-dihydrobiochanin A + NADP+
-
-
-
?
6,7-dihydroxy-4'-methoxyisoflavone + NADPH + H+
(3S)-2-dihydrobiochanin A + NADP+
-
highly specific for 5,7-hydroxy group and some specificity for 4'-substituent of isoflavones, no reaction with flavones, chalcones, 5-deoxyisoflavones
hydrated at 2 position or ring A of isoflavone
?
6,7-dihydroxy-4'-methoxyisoflavone + NADPH + H+
(3S)-2-dihydrobiochanin A + NADP+
-
trivial name biochanin A
hydrated at 2 position or ring A of isoflavone
?
6,7-dihydroxy-4'-methoxyisoflavone + NADPH + H+
(3S)-2-dihydrobiochanin A + NADP+
-
trivial name biochanin A
incorporation of pro-R hydrogen from NADPH, i.e. A-specific
?
