1.3.1.45: 2'-hydroxyisoflavone reductase
This is an abbreviated version!
For detailed information about 2'-hydroxyisoflavone reductase, go to the full flat file.
Word Map on EC 1.3.1.45
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1.3.1.45
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isoflavonoids
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phytoalexins
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medicarpin
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phenylcoumaran
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pisatin
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pinoresinol-lariciresinol
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pterocarpans
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thaumatin-like
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pollinosis
- 1.3.1.45
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isoflavonoids
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phytoalexins
- medicarpin
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phenylcoumaran
- pisatin
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pinoresinol-lariciresinol
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pterocarpans
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thaumatin-like
- pollinosis
Reaction
Synonyms
CaIRL, GbIRL1, GmIFR, IFH, IFR, IRL, isoflavone 2'-hydroxylase, isoflavone reductase, isoflavone reductase-like protein, LOC100786578, More, NADPH-dependent isoflavone reductase, NADPH:2'-hydroxyisoflavone oxidoreductase, Ole e 12, OsIRL, PvIFR1, reductase, 2',7-dihydroxy-4',5'-methylenedioxyisoflavone, reductase, 2'-hydroxyisoflavone
ECTree
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General Information
General Information on EC 1.3.1.45 - 2'-hydroxyisoflavone reductase
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evolution
malfunction
metabolism
physiological function
additional information
the enzyme contains a conserved nitrogen metabolite repression regulator (NmrA) domain and a phenylcoumaran benzylic ether reductase (PCBER) domain
isoflavone reductases (IFRs) are unique to the plant kingdom. The enzyme is a member of the soybean isoflavone reductase gene family GmIF
evolution
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the allergen, named Ole e 12, is a polymorphic isoflavone reductase-like protein of 308 amino acids showing 80% and 74% identity with birch and pear allergens, Bet v 6 and Pyr c 5, respectively. Analysis of the presence of Ole e 12 homologues in different pollens from other species, overview
evolution
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the enzyme is a member of the isoflavone reductase gene family
transgenic rice lines overexpressing the OsIRL gene under an abscisic acid inducible promoter are tolerant against methyl viologen (MV) and glucose/glucose oxidase-induced stress in rice leave and suspension-cultured cells
malfunction
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knockdown of PvIFR1 mediated by RNA interference (RNAi) in common bean composite plants results in a reduction of shoot and root length. Reduction of PvIFR1 mRNAs also affects growth of lateral roots after emergence, a stage in which auxins are required to establish a persistent meristem. Upon inoculation, the number of nodules formed by different strains of Rhizobium etli is significantly lower in IFR RNAi than in control roots. Transcript levels of two auxin-regulated genes are consistent with lower levels of auxin in PvIFR1 silenced roots. No differences in mRNA levels of PvIFR1 are observed between shoots of IFR and GUS RNAi composite plants, indicating that the shoot phenotype is not caused by systemic silencing of PvIFR1. Root phenotype, overview
FcIRL belongs to the class of pinoresinol-lariciresinol reductase, PRL, functioning in the biosynthesis of 8,8'-linked lignans, with function in catalyzing reduction of pinoresinol and lariciresinol into secoisolariciresinol, and medicinal secondary metabolism and resistance in Fagopyrum cymosum
metabolism
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the enzyme participates in the last steps of the biosynthetic pathway of isoflavonoids
isoflavonereductase (IFR)is an enzyme involved in the biosynthetic pathway of isoflavonoid phytoalexin in plants. The enzyme is considered to have a crucial role in plant response to various biotic and abiotic environmental stresses. Overexpression of soybean isoflavone reductase (GmIFR) enhances resistance to Phytophthora sojae in soybean. Enzyme GmIFR might play an important role as an antioxidant to reduce ROS in soybean
physiological function
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the 37-kDa enzyme protein seems to be associated to the IgE-binding profile of a group of patients suffering allergy to peach and olive pollen. The allergen, named Ole e 12, is a polymorphic isoflavone reductase-like protein of 308 amino acids showing 80% and 74% identity with birch and pear allergens, Bet v 6 and Pyr c 5, respectively. Ole e 12 is a minor olive pollen allergen, which gains relevance in patients allergic to peach with olive pollinosis
physiological function
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enzyme gene expression is associated with wheat yield performance under heat stress at anthesis