1.3.1.24: biliverdin reductase
This is an abbreviated version!
For detailed information about biliverdin reductase, go to the full flat file.
Word Map on EC 1.3.1.24
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1.3.1.24
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heme
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oxygenase-1
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monoxide
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cytoprotective
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repolarization
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beat-to-beat
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rosenthal
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hyperbilirubinemia
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palliation
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tetrapyrrole
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tdp
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torsades
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diagnostics
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proarrhythmia
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medicine
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galenic
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univentricular
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pharmacology
- 1.3.1.24
- heme
- oxygenase-1
-
monoxide
-
cytoprotective
-
repolarization
-
beat-to-beat
-
rosenthal
-
hyperbilirubinemia
-
palliation
- tetrapyrrole
- tdp
-
torsades
- diagnostics
-
proarrhythmia
- medicine
-
galenic
-
univentricular
- pharmacology
Reaction
Synonyms
biliverdin IXalpha reductase, biliverdin IXbeta reductase, biliverdin reductase, biliverdin reductase A, biliverdin reductase B, Biliverdin reductase-A, biliverdin-IXalpha reductase, BLVR subtype B, BLVRA, BLVRB, BV reductase, BVR, BVR-A, BVR-B, BVRA, BVRB, F-BVR, F420H2-dependent biliverdin reductase, hBVR, hBVR-A, reductase, biliverdin, Rv2074, slr1784
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Localization
Localization on EC 1.3.1.24 - biliverdin reductase
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in normoxic cells, hBVR is located primarily in the cytoplasm, with some protein also being seen in the nucleus
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role for the enzyme in intracellular traffic of protein kinase C betaII and its membrane translocation
in the nucleus, BVR is a leucine zipper-like DNA binding protein and can act as a transcription factor for activator protein 1-regulated genes
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hBVR is detected in the nucleus at 1, 2, and 4 h after hypoxia, at which times its kinase and reductase activities are increased
in the nucleus, BVR is a leucine zipper-like DNA binding protein and can act as a transcription factor for activator protein 1-regulated genes
eNOS-generated NO, in part, translocates the enzyme into the nucleus, where BLVRA inhibits toll-like receptor 4 (TLR4) expression