1.3.1.22: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.22

1.3.1.22

androgen

prostate

dihydrotestosterone

srd5a2

finasteride

genitalia

5alpha-reduced

hypospadias

3alpha-hydroxysteroid

pseudohermaphroditism

5alpha-r1

medicine

5alpha-reduction

17beta-hsds

1.3.99.5

hirsutism

17beta-hydroxysteroid

virilization

pharmacology

analysis

Reaction

Synonyms

3-oxosteroid 5alpha-reductase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, 4-ene-5alpha-reductase, 5 alpha-R2, 5 alpha-reductase type 2, 5-alpha reductase I, 5-alpha reductase II, 5-alpha-reductase type 1, 5-alpha-reductase type 2, 5a-reductase type 1, 5a-reductase type 2, 5A2, 5alpha-R1, 5alpha-R2, 5alpha-reductase 1, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-SR2, 5alphaR, 5alphaR type 2, 5alphaR1, 5alphaR2, AtDET2, brainneurosteroidogenic 5x02-reductase 1, cholest-4-en-3-one 5alpha-reductase, cortisone alpha-reductase, cortisone DELTA 4-5alphareductase, DCC71_03205, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-ketosteroid reductase (5alpha), DELTA4-3-oxosteroid-5 alpha-reductase, DELTA4-5alpha-reductase, DELTA4-steroid 5alpha-reductase (progesterone), EC 1.3.1.30, EC 1.3.1.4, LeDET2, microsomal steroid reductase (5alpha), More, NADPH:DELTA4-3-oxosteroid-5alpha-oxidoreductase, neurosteroidogenic 5alpha-reductase 1, progesterone 5alpha-reductase, reduced nicotinamide adenine dinucleotide phosphate:DELTA4-3-ketosteroid 5alpha-oxidoreductase, reductase, cholestenone 5alpha-, reductase, cortisone DELTA: 4-5alpha-, reductase, progesterone 5alpha-, S5alphaR, SRD5A1, SRD5A2, SRDA1, SRDA2, SRDA3, steroid 5-alpha reductase, steroid 5-alpha-reductase, steroid 5alpha reductase type 2, steroid 5alpha-hydrogenase, steroid 5alpha-reductase, steroid 5alpha-reductase type II, testosterone 5alpha-reductase, testosterone delta4-5alpha-reductase, testosterone delta4-hydrogenase, type 1 5alpha-reductase, type 1 5alphaR, type 1 SR, type 1 steroid 5alpha reductase, type 1 steroid 5alpha-reductase, type 2 5alpha-reductase, type 2 5alphaR, type 2 SR, type 2 steroid 5alpha reductase, type 2 steroid 5alpha-reductase, type II 5alpha-reductase, type-1 5alpha-reductase, type-2 5alpha-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

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Results	in table
19	Activating Compound
2076	AA Sequence
14	Application
3	CAS Registry Number
13	Cloned(Commentary)
96	Cofactor
3	Crystallization (Commentary)
278	Disease/ Diagnostics
4	Expression
3	General Information
4	General Stability
61	IC50 Value
447	Inhibitors
80	Ki Value [mM]
98	KM Value [mM]
56	Localization
6	Metals/Ions
7	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
158	Organism
13	Pathway
1	PDB ID
38	pH Optimum
9	pH Range
2	pH Stability
41	Protein Variants
6	Purification (Commentary)
8	Reaction
3	Reaction Type
154	Reference
1	Renatured (Commentary)
169	Source Tissue
14	Specific Activity [micromol/min/mg]
4	Storage Stability
172	Substrates and Products (Substrate)
4	Subunits
134	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.3.1.22 - 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

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5alpha-pregnan-3,20-dione + NADP+

progesterone + NADPH + H+

Mus musculus

710797

progesterone + NADPH + H+

5alpha-pregnan-3-20-dione + NADP+

9 entries

testosterone + NADPH + H+

17beta-hydroxy-5alpha-androstan-3-one + NADP+

2 entries

testosterone + NADPH + H+

5alpha-dihydrotestosterone + NADP+

7 entries

testosterone + NADPH + H+

dihydrotestosterone + NADP+

Rattus norvegicus

P24008

762009, 762014

additional information

Rattus norvegicus

role of enzyme in initiation of spermatogenensis

654933