1.3.1.15: dihydroorotate dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
reductase, orotate (reduced nicotinamide adenine dinucleotide phosphate), triphosphopyridine-linked dihydroorotic dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.3.1.15 - dihydroorotate dehydrogenase (NADP+)
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REACTION DIAGRAM
5-fluoroorotate + NADPH
(S)-5-fluorodihydroorotate + NADP+
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enzyme exhibits very weak oxidase activity
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?
orotate + NADPH
(S)-dihydroorotate + NADP+
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enzyme is 20fold less active with NADH as cofactor
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?