1.3.1.107: sanguinarine reductase

This is an abbreviated version!
For detailed information about sanguinarine reductase, go to the full flat file.

Reaction

Synonyms

SARED1

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.107 sanguinarine reductase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
1	General Information
1	KM Value [mM]
1	Localization
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
3	Organism
2	Pathway
1	pH Optimum
7	Protein Variants
1	Purification (Commentary)
4	Reaction
3	Reference
9	Substrates and Products (Substrate)
1	Subunits
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.3.1.107 - sanguinarine reductase

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dihydrosanguinarine:NAD(P)+ oxidoreductase

The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1].