1.3.1.1: dihydropyrimidine dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.3.1.1
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1.3.1.1
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thymidine
-
riboflavin
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1.3.1.2
-
phosphorylase
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thymidylate
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5-fluorouracil
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medicine
-
2.4.2.4
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immunotitration
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2.1.1.45
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2.7.1.21
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monofunctional
-
12-o-tetradecanoylphorbol-13-acetate
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tpa-treated
-
e-5-2-bromovinyl-2'-deoxyuridine
-
analysis
- 1.3.1.1
- thymidine
- riboflavin
-
1.3.1.2
- phosphorylase
- thymidylate
- 5-fluorouracil
- medicine
-
2.4.2.4
-
immunotitration
-
2.1.1.45
-
2.7.1.21
-
monofunctional
- 12-o-tetradecanoylphorbol-13-acetate
-
tpa-treated
-
e-5-2-bromovinyl-2'-deoxyuridine
- analysis
Reaction
Synonyms
dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase
ECTree
1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-fluorouracil + NAD+
? + NADH
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rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine
-
-
r
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
-
-
-
?
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
-
-
-
?
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
-
-
r
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
-
-
-
?
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
-
dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine
-
?
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
dihydropyrimidine dehydrogenase is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil
-
-
?
5-fluorouracil + NADH + H+
5-fluoro-5,6-dihydrouracil + NAD+
-
development of a detection method using 2'-fluoro-beta-alanine derivatization with o-phthalaldehyde at room temperature and mass spectrometric analysis by the liquid chromatography-mass spectrometry-electrospray ionization system, method evaluation and optimization, overview
dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine
-
?
uracil + NAD(P)H + H+
5,6-dihydrouracil + NAD(P)+
Clostridium uracilicum
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high specificity for uracil
-
r
uracil + NAD(P)H + H+
5,6-dihydrouracil + NAD(P)+
Clostridium uracilicum
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reductive pathway of uracil degradation
-
?
uracil + NAD(P)H + H+
5,6-dihydrouracil + NAD(P)+
-
preferred substrate
-
-
?
additional information
?
-
-
the enzyme does not use NADPH as cosubstrate
-
-
?
additional information
?
-
-
the enzyme does not use NADPH as cosubstrate
-
-
?
