1.3.1.1: dihydropyrimidine dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.3.1.1

1.3.1.1

thymidine

riboflavin

1.3.1.2

phosphorylase

thymidylate

5-fluorouracil

medicine

2.4.2.4

immunotitration

2.1.1.45

2.7.1.21

monofunctional

12-o-tetradecanoylphorbol-13-acetate

tpa-treated

e-5-2-bromovinyl-2'-deoxyuridine

analysis

Reaction

Synonyms

dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)

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Results	in table
5	Activating Compound
737	AA Sequence
5	Application
1	CAS Registry Number
1	Cloned(Commentary)
23	Cofactor
1	Crystallization (Commentary)
4	Disease/ Diagnostics
2	Expression
3	General Information
7	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
4	Localization
5	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
42	Organism
4	Pathway
4	pH Optimum
1	pH Range
2	Protein Variants
3	Purification (Commentary)
2	Reaction
3	Reaction Type
30	Reference
39	Source Tissue
8	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
2	Subunits
49	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)

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5,6-dihydrouracil + NAD+

uracil + NADH + H+

Homo sapiens

656359

5-fluorouracil + NAD+

? + NADH

Homo sapiens

rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine

656359

5-fluorouracil + NADH + H+

5-fluoro-5,6-dihydrouracil + NAD+

Homo sapiens

712566

dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine

5-fluorouracil + NADPH + H+

5-fluoro-5,6-dihydrouracil + NADP+

2 entries

thymine + NADH + H+

5,6-dihydrothymine + NAD+

2 entries

uracil + NAD(P)H + H+

5,6-dihydrouracil + NAD(P)+

Clostridium uracilicum

reductive pathway of uracil degradation

349140

uracil + NADH + H+

5,6-dihydrouracil + NAD+

2 entries

additional information

2 entries