1.3.1.1: dihydropyrimidine dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.3.1.1
-
1.3.1.1
-
thymidine
-
riboflavin
-
1.3.1.2
-
phosphorylase
-
thymidylate
-
5-fluorouracil
-
medicine
-
2.4.2.4
-
immunotitration
-
2.1.1.45
-
2.7.1.21
-
monofunctional
-
12-o-tetradecanoylphorbol-13-acetate
-
tpa-treated
-
e-5-2-bromovinyl-2'-deoxyuridine
-
analysis
- 1.3.1.1
- thymidine
- riboflavin
-
1.3.1.2
- phosphorylase
- thymidylate
- 5-fluorouracil
- medicine
-
2.4.2.4
-
immunotitration
-
2.1.1.45
-
2.7.1.21
-
monofunctional
- 12-o-tetradecanoylphorbol-13-acetate
-
tpa-treated
-
e-5-2-bromovinyl-2'-deoxyuridine
- analysis
Reaction
Synonyms
dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase
ECTree
Advanced search results
Engineering
Engineering on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
additional information
-
mutation IVS14+1G>A results in a 165bp deletion (corresponding to exon 14) in the DPD mRNA, the resulting protein product is truncated by 55 amino acids, and its catalytic activity is virtually absent, the mutation is responsible for a significant proportion of life-threatening toxicity of 5-fluorouracil
additional information
-
the splice-site polymorphism IVS14+1G>A results in severe DPD deficiency with absent DPD activity