1.21.4.3: sarcosine reductase
This is an abbreviated version!
For detailed information about sarcosine reductase, go to the full flat file.
Reaction
ECTree
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Systematic Name
Systematic Name on EC 1.21.4.3 - sarcosine reductase
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acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming)
The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.4 (betaine reductase).