1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring)

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For detailed information about oxoglutarate dehydrogenase (succinyl-transferring), go to the full flat file.

Reaction

Synonyms

2-ketoglutarate dehydrogenase, 2-OGDH, 2-OGDH E1, 2-OGDH1, 2-OGDH2, 2-oxoadipate dehydrogenase, 2-oxoglutarate decarboxylase, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex E1 component, 2-oxoglutarate dehydrogenase E1/E2 component, 2-oxoglutarate dehydrogenase-like protein, 2-oxoglutarate:lipoate oxidoreductase, 2OGDH, AKGDH, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-ketoglutarate dehydrogenase multienzyme complex, alpha-ketoglutaric acid dehydrogenase, alpha-ketoglutaric dehydrogenase, alpha-KGD, alpha-KGDH, alpha-KGDHC, alpha-oxoglutarate dehydrogenase, alphaKGDH, At3g55410, dehydrogenase, oxoglutarate, DHTKD1, E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex, E1 subunit of the alpha-ketoglutarate dehydrogenase complex, E1-OGDH1, E1-OGDH2, E1a, E1k, E1o, E1o component, E1o component 2-oxoglutarate dehydrogenase complex, ELK, ilvB, KDH, Kdh E1, ketoglutaric dehydrogenase, KG dehydrogenase, Kgd, KGDH, KGDHC, MPA24.10, OADH, ODH, OdhA, OGDC, OGDH, OGDHC, OGDHL, oxoglutarate decarboxylase, oxoglutarate dehydrogenase, SucA, ThDP-dependent 2-oxoglutarate dehydrogenase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.4 With a disulfide as acceptor

                1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)

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Results	in table
15	Activating Compound
28995	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
39	Cofactor
3	Crystallization (Commentary)
647	Disease/ Diagnostics
20	General Information
21	Inhibitors
26	kcat/KM [mM/s]
27	Ki Value [mM]
37	KM Value [mM]
32	Localization
20	Metals/Ions
10	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
93	Organism
7	Pathway
72	PDB ID
8	pH Optimum
2	pH Range
2	Posttranslational Modification
22	Protein Variants
13	Purification (Commentary)
21	Reaction
4	Reaction Type
63	Reference
52	Source Tissue
9	Specific Activity [micromol/min/mg]
70	Substrates and Products (Substrate)
10	Subunits
125	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
26	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.2.4.2 - oxoglutarate dehydrogenase (succinyl-transferring)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-oxoglutarate + lipoamide

S-succinyldihydrolipoamide + CO2

Saccharomyces cerevisiae

-

transcription of the 2-oxoglutarate dehydrogenase component of the 2-oxoglutarate dehydrogenase complex is regulated by glucose and activated by the products of HAP2 and HAP3

348999

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

20 entries

additional information

?

-

7 entries

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Arabidopsis thaliana

F4IWV2, Q9FLH2

-

759969

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Cavia porcellus

-

-

656595

-

-

ir

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Corynebacterium glutamicum

-

-

719719

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Corynebacterium glutamicum ATCC 13032

-

-

719719

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Escherichia coli

-

-

762591

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Escherichia coli

P0AFG3

-

763425

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Homo sapiens

-

-

740732, 759216

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Homo sapiens

Q02218

-

759216

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Homo sapiens

-

-

762763, 762764, 763053

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Homo sapiens

Q96HY7; Q02218

-

763053

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Mus musculus

-

-

762764

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Mus musculus

-

-

656596

-

-

ir

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Plasmodium falciparum

-

-

656835

-

-

ir

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Rattus norvegicus

-

-

740535, 762764

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Rattus norvegicus

-

-

656596

-

-

ir

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Rattus norvegicus

Q4KLP0, Q5XI78

-

763067

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Salmonella enterica subsp. enterica serovar Typhimurium

O87668

-

656572

-

-

ir

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Sus scrofa

-

-

740480

-

-

?

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Sus scrofa

-

-

656595

-

-

ir

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2

Urocitellus richardsonii

-

-

762766

-

-

?

additional information

?

-

Cavia porcellus

-

enzyme also catalyzes the production of H2O2 in vivo, in vitro, and in situ from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a atrget for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview

656595

-

-

?

additional information

?

-

Corynebacterium glutamicum

-

OdhA can utilize free dihydrodilipoamide to perform the E2 reaction specifically with succinyl-CoA. OdhA specifically catalyzes the E1 and E2 reaction to convert 2-oxoglutarate to succinyl-CoA but fully relies on the lipoyl residues provided by AceF involved in the reactions to convert pyruvate to acetyl-CoA

719719

-

-

?

additional information

?

-

Corynebacterium glutamicum ATCC 13032

-

OdhA can utilize free dihydrodilipoamide to perform the E2 reaction specifically with succinyl-CoA. OdhA specifically catalyzes the E1 and E2 reaction to convert 2-oxoglutarate to succinyl-CoA but fully relies on the lipoyl residues provided by AceF involved in the reactions to convert pyruvate to acetyl-CoA

719719

-

-

?

additional information

?

-

Mus musculus

-

enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview

656596

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview

656596

-

-

?

additional information

?

-

Rattus norvegicus

-

the E1o component of the2-oxoglutarate dehydrogenase complex catalyses the initial, substrate-specific and irreversible stage of the overall reaction, and has the lowest catalytic activity (turnover number) among the components and as such limits the rate of the overall process

696124

-

-

?

additional information

?

-

Sus scrofa

-

enzyme also catalyzes the production of H2O2 from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a target for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview

656595

-

-

?