1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring)

This is an abbreviated version!
For detailed information about oxoglutarate dehydrogenase (succinyl-transferring), go to the full flat file.

Reaction

Synonyms

2-ketoglutarate dehydrogenase, 2-OGDH, 2-OGDH E1, 2-OGDH1, 2-OGDH2, 2-oxoadipate dehydrogenase, 2-oxoglutarate decarboxylase, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex E1 component, 2-oxoglutarate dehydrogenase E1/E2 component, 2-oxoglutarate dehydrogenase-like protein, 2-oxoglutarate:lipoate oxidoreductase, 2OGDH, AKGDH, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-ketoglutarate dehydrogenase multienzyme complex, alpha-ketoglutaric acid dehydrogenase, alpha-ketoglutaric dehydrogenase, alpha-KGD, alpha-KGDH, alpha-KGDHC, alpha-oxoglutarate dehydrogenase, alphaKGDH, At3g55410, dehydrogenase, oxoglutarate, DHTKD1, E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex, E1 subunit of the alpha-ketoglutarate dehydrogenase complex, E1-OGDH1, E1-OGDH2, E1a, E1k, E1o, E1o component, E1o component 2-oxoglutarate dehydrogenase complex, ELK, ilvB, KDH, Kdh E1, ketoglutaric dehydrogenase, KG dehydrogenase, Kgd, KGDH, KGDHC, MPA24.10, OADH, ODH, OdhA, OGDC, OGDH, OGDHC, OGDHL, oxoglutarate decarboxylase, oxoglutarate dehydrogenase, SucA, ThDP-dependent 2-oxoglutarate dehydrogenase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.4 With a disulfide as acceptor

                1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
15	Activating Compound
28995	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
39	Cofactor
3	Crystallization (Commentary)
647	Disease/ Diagnostics
20	General Information
21	Inhibitors
26	kcat/KM [mM/s]
27	Ki Value [mM]
37	KM Value [mM]
32	Localization
20	Metals/Ions
10	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
93	Organism
7	Pathway
72	PDB ID
8	pH Optimum
2	pH Range
2	Posttranslational Modification
22	Protein Variants
13	Purification (Commentary)
21	Reaction
4	Reaction Type
63	Reference
52	Source Tissue
9	Specific Activity [micromol/min/mg]
70	Substrates and Products (Substrate)
10	Subunits
125	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
26	Turnover Number [1/s]

Application

print visible entries

print all entries

Application on EC 1.2.4.2 - oxoglutarate dehydrogenase (succinyl-transferring)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

industry

Corynebacterium glutamicum

-

ODH is essential for glutamine utilization, regulatory mechanisms of reduced ODH activity that is essential for the industrial production of 1.5 million tons per year of glutamate with Corynebacterium glutamicum

674539

synthesis

Escherichia coli

P0AFG3

expression of the structural genes for all three subunits of the Escherichia coli 2-oxoglutarate dehydrogenase complex in Saccharomyces cerevisiae. The Escherichia coli lipoic-acid scavenging enzyme is coexpressed to enable cytosolic lipoylation of the complex, which is required for its enzymatic activity. In vivo cytosolic activity of the complex is tested by constructing a reporter strain in which the essential metabolite 5-aminolevulinic acid can only be synthetized from cytosolic, and not mitochondrial, succinyl-CoA. In the resulting strain, complementation of 5-aminolevulinic acid auxotrophy depends on activation of the 2-oxoglutarate dehydrogenase complex by lipoic acid addition

763425