1.2.4.1: pyruvate dehydrogenase (acetyl-transferring)

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase (acetyl-transferring), go to the full flat file.

Reaction

Synonyms

aceE, AcoA, CTHT_0006350, CTHT_0069820, dehydrogenase, pyruvate, E1 component of pyruvate dehydrogenase, E1 component of pyruvate dehydrogenase multienzyme complex, E1 component of the pyruvate dehydrogenase multienzyme complex, E1 component subunit alpha, E1 component subunit beta, E1alpha, E1ec, E1p, IAR4, MAB1, MdeB, mitochondrial pyruvate dehydrogenase, More, MtPDC, OsI_14647, OsI_31986, Pda1, PDC, PDH, PDH E1alpha, PDH subunit E1-beta, PDH-A1, PDHa, PdhA1, PDHA1a, PdhB, PDHC, PDHc E1, PDHc-E1, PdhE, PDHE1alpha, PdhH, PH2, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase complex, pyruvate dehydrogenase complex E1 component, pyruvate dehydrogenase complex,, pyruvate dehydrogenase E1, pyruvate dehydrogenase E1 alpha subunit, pyruvate dehydrogenase E1 component, pyruvate dehydrogenase E1 component subunit beta, pyruvate dehydrogenase multienzyme complex, pyruvate dehydrogenase multienzyme complex E1, pyruvate dehydrogenase, E1, pyruvate:NAD oxidoreductase, pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating), pyruvic acid dehydrogenase, pyruvic dehydrogenase, thiamin diphosphate-dependent pyruvate dehydrogenase, thiamin-dependent pyruvate dehydrogenase, thiamine diphosphate-dependent 2-oxo acid decarboxylase, VEG220, Vegetative protein 220

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.4 With a disulfide as acceptor

                1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
60141	AA Sequence
15	Application
1	CAS Registry Number
26	Cloned(Commentary)
53	Cofactor
11	Crystallization (Commentary)
2058	Disease/ Diagnostics
3	Expression
13	General Information
7	General Stability
16	IC50 Value
116	Inhibitors
5	kcat/KM [mM/s]
8	Ki Value [mM]
56	KM Value [mM]
28	Localization
23	Metals/Ions
26	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
92	Organism
10	Pathway
118	PDB ID
12	pH Optimum
1	pH Range
1	pH Stability
18	Posttranslational Modification
64	Protein Variants
17	Purification (Commentary)
9	Reaction
3	Reaction Type
92	Reference
1	Renatured (Commentary)
51	Source Tissue
30	Specific Activity [micromol/min/mg]
7	Storage Stability
83	Substrates and Products (Substrate)
21	Subunits
106	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
45	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.2.4.1 - pyruvate dehydrogenase (acetyl-transferring)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)

Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex, EC 1.2.1.104, in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.