1.2.4.1: pyruvate dehydrogenase (acetyl-transferring)

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For detailed information about pyruvate dehydrogenase (acetyl-transferring), go to the full flat file.

Reaction

Synonyms

aceE, AcoA, CTHT_0006350, CTHT_0069820, dehydrogenase, pyruvate, E1 component of pyruvate dehydrogenase, E1 component of pyruvate dehydrogenase multienzyme complex, E1 component of the pyruvate dehydrogenase multienzyme complex, E1 component subunit alpha, E1 component subunit beta, E1alpha, E1ec, E1p, IAR4, MAB1, MdeB, mitochondrial pyruvate dehydrogenase, More, MtPDC, OsI_14647, OsI_31986, Pda1, PDC, PDH, PDH E1alpha, PDH subunit E1-beta, PDH-A1, PDHa, PdhA1, PDHA1a, PdhB, PDHC, PDHc E1, PDHc-E1, PdhE, PDHE1alpha, PdhH, PH2, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase complex, pyruvate dehydrogenase complex E1 component, pyruvate dehydrogenase complex,, pyruvate dehydrogenase E1, pyruvate dehydrogenase E1 alpha subunit, pyruvate dehydrogenase E1 component, pyruvate dehydrogenase E1 component subunit beta, pyruvate dehydrogenase multienzyme complex, pyruvate dehydrogenase multienzyme complex E1, pyruvate dehydrogenase, E1, pyruvate:NAD oxidoreductase, pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating), pyruvic acid dehydrogenase, pyruvic dehydrogenase, thiamin diphosphate-dependent pyruvate dehydrogenase, thiamin-dependent pyruvate dehydrogenase, thiamine diphosphate-dependent 2-oxo acid decarboxylase, VEG220, Vegetative protein 220

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.4 With a disulfide as acceptor

                1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

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Results	in table
2	Activating Compound
60141	AA Sequence
15	Application
1	CAS Registry Number
26	Cloned(Commentary)
53	Cofactor
11	Crystallization (Commentary)
2058	Disease/ Diagnostics
3	Expression
13	General Information
7	General Stability
16	IC50 Value
116	Inhibitors
5	kcat/KM [mM/s]
8	Ki Value [mM]
56	KM Value [mM]
28	Localization
23	Metals/Ions
26	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
92	Organism
10	Pathway
118	PDB ID
12	pH Optimum
1	pH Range
1	pH Stability
18	Posttranslational Modification
64	Protein Variants
17	Purification (Commentary)
9	Reaction
3	Reaction Type
92	Reference
1	Renatured (Commentary)
51	Source Tissue
30	Specific Activity [micromol/min/mg]
7	Storage Stability
83	Substrates and Products (Substrate)
21	Subunits
106	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
45	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 1.2.4.1 - pyruvate dehydrogenase (acetyl-transferring)

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-18°C, 50 mM potassium phosphate, pH 7.0, 0.5 mM EDTA, several months, no loss of activity

Sus scrofa

-

348974

-20°C, 2 weeks, 10-20% loss of activity

Pisum sativum

-

348936

-20°C, 50 mM phosphate buffer, pH 7.0, several months, no loss of activity

Escherichia coli

-

348981

-20°C, N2-atmosphere, addition of sulfhydryl compounds, several weeks

Brassica oleracea

-

348951

-20°C, stable for several months

Pseudomonas putida

O33468

736649

-50°C, 50 mM potassium phosphate buffer, pH 7.0, 1 mM MgCl2, 20 mM thiamine diphosphate, 0.1 mM EDTA, 0.4 mM DTT, 0.1 mM NAD+, several months

Bos taurus

-

348955

4°C, recombinant enzyme in saturated ammonium sulfate, pH 7.0, stabel for 6 months

Azotobacter vinelandii

V9H1F5

759139