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0.96 - 3.39
2,4-dihydroxybenzaldehyde
6.88 - 21.32
2-hydroxypyrimidine
0.64 - 6.89
2-Methoxybenzaldehyde
1.9 - 6.2
3-Methoxybenzaldehyde
0.51 - 1.94
4-(dimethylamino)cinnamaldehyde
0.53 - 4.31
4-hydroxybenzaldehyde
2.14 - 7.37
4-methoxybenzaldehyde
0.52 - 2.41
4-nitrobenzaldehyde
0.005 - 1.31
5-nitroquinoline
-
1.67 - 2.95
cinnamaldehyde
436.5
cinnamylaldehyde
-
partially purified protein, pH 7.0, 30°C
1.22 - 8.32
crotonaldehyde
1.24 - 6.35
ethyl vanillin
1904
Indole-3-acetaldehyde
-
partially purified protein, pH 7.0, 30°C
0.447 - 1.97
N-methylnicotinamide
0.38 - 1.92
N1-methyl-nicotineamide
0.052 - 0.82
N1-methylnicotinamide
0.18 - 9.68
phenanthridine
0.47 - 4.66
phenylacetaldehyde
0.53 - 6.32
phenylpropionaldehyde
0.66 - 5.06
propionaldehyde
0.18 - 2.05
retinalaldehyde
0.022 - 0.83
retinaldehyde
0.39 - 11.25
Salicylaldehyde
additional information
additional information
further kinetic parameters of phthalazine-DCPIP reaction in the absence or presence of the inhibitors benzamidine, menadione, norharmane, and raloxifene available in the publication
-
0.96
2,4-dihydroxybenzaldehyde
pH 8, 37°C
1.65
2,4-dihydroxybenzaldehyde
pH 8, 37°C
1.86
2,4-dihydroxybenzaldehyde
pH 8, 37°C
3.39
2,4-dihydroxybenzaldehyde
wild-type, pH 8.0, 37°C
6.88
2-hydroxypyrimidine
-
apparent Kcat-value of recombinant mAOX3, pH 7.4, 25°C
21.32
2-hydroxypyrimidine
-
apparent Kcat-value of native mAOX3, pH 7.4, 25°C
0.64
2-Methoxybenzaldehyde
pH 8, 37°C
6.89
2-Methoxybenzaldehyde
pH 8, 37°C
1.9
3-Methoxybenzaldehyde
pH 8, 37°C
4.3
3-Methoxybenzaldehyde
pH 8, 37°C
6.2
3-Methoxybenzaldehyde
pH 8, 37°C
0.51
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.51
4-(dimethylamino)cinnamaldehyde
wild-type, pH 8.0, 37°C
0.75
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.75
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.47
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.47
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.94
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.94
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.53
4-hydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.91
4-hydroxybenzaldehyde
pH 8, 37°C
1.94
4-hydroxybenzaldehyde
pH 8, 37°C
4.31
4-hydroxybenzaldehyde
pH 8, 37°C
2.14
4-methoxybenzaldehyde
pH 8, 37°C
3.75
4-methoxybenzaldehyde
pH 8, 37°C
7.37
4-methoxybenzaldehyde
pH 8, 37°C
0.52
4-nitrobenzaldehyde
wild-type, pH 8.0, 37°C
1.57
4-nitrobenzaldehyde
pH 8, 37°C
2.12
4-nitrobenzaldehyde
pH 8, 37°C
2.41
4-nitrobenzaldehyde
pH 8, 37°C
0.005
5-nitroquinoline
metabolite 2-oxo-5-aminoquinoline, pH 7.4, 37°C
-
0.133
5-nitroquinoline
metabolite 2-oxo-5-nitroquinoline, pH 7.4, 37°C
-
0.18
5-nitroquinoline
metabolite 5-aminoquinoline, presence of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide, pH 7.4, 37°C
-
1.31
5-nitroquinoline
metabolite 2-oxo-5-nitroquinoline, presence of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide, pH 7.4, 37°C
-
1.48
acetaldehyde
pH 8, 37°C
2.7
acetaldehyde
mutant V806E, 30°C, pH 7.4
3.31
acetaldehyde
wild-type, pH 8.0, 37°C
5.81
acetaldehyde
pH 8, 37°C
7.04
acetaldehyde
pH 8, 37°C
8.66
acetaldehyde
wild-type, 30°C, pH 7.4
0.27
allopurinol
mutant F1014V, pH 8.0,37°C
0.62
allopurinol
mutant P1015G, pH 8.0,37°C
0.77
allopurinol
mutant P1015A, pH 8.0,37°C
1.22
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
1.22
allopurinol
wild-type, pH 8.0,37°C
1.58
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.17
benzaldehyde
E1266Q mutant, pH 8.0, 37°C
0.31
benzaldehyde
mutant F1014I, pH 8.0,37°C
0.32
benzaldehyde
K889H mutant, pH 8.0, 37°C
0.39
benzaldehyde
mutant V1016I, pH 8.0, 37°C
0.47
benzaldehyde
mutant V1016L, pH 8.0, 37°C
0.59
benzaldehyde
mutant M1088V, pH 8.0, 37°C
0.66
benzaldehyde
mutant V1016F, pH 8.0, 37°C
0.683
benzaldehyde
A807V mutant, pH 8.0, 37°C
0.698
benzaldehyde
mAOX3 wild type, pH 8.0, 37°C
0.727
benzaldehyde
A807V/Y885M double mutant, pH 8.0, 37°C
0.733
benzaldehyde
-
apparent Kcat-value of recombinant mAOX3, pH 7.4, 25°C
0.957
benzaldehyde
Y885M mutant, pH 8.0, 37°C
1.13
benzaldehyde
wild-type, pH 8.0,37°C
1.14
benzaldehyde
mutant I1018K, pH 8.0, 37°C
1.25
benzaldehyde
mutant I1018S, pH 8.0, 37°C
1.27
benzaldehyde
mutant M884R, 30°C, pH 7.4
1.27
benzaldehyde
mutant P1015A, pH 8.0,37°C
1.52
benzaldehyde
wild-type, pH 8.0, 37°C
1.55
benzaldehyde
mutant P1015G, pH 8.0,37°C
2.13
benzaldehyde
mutant F1014V, pH 8.0,37°C
2.167
benzaldehyde
-
apparent Kcat-value of native mAOX3, pH 7.4, 25°C
2.51
benzaldehyde
pH 8, 37°C
2.52
benzaldehyde
mutant V806E, 30°C, pH 7.4
3.51
benzaldehyde
pH 8, 37°C
3.9
benzaldehyde
mutant F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L, pH 8.0,37°C
4.7
benzaldehyde
pH 8, 37°C
5.29
benzaldehyde
wild-type, 30°C, pH 7.4
5.32
benzaldehyde
mutant M1088T, pH 8.0, 37°C
95.2
benzaldehyde
-
partially purified protein, pH 7.0, 30°C
0.63
Butanal
pH 8, 37°C
1.84
Butanal
wild-type, pH 8.0, 37°C
2.333
Butanal
-
apparent Kcat-value of recombinant mAOX3, pH 7.4, 25°C
6.4
Butanal
-
apparent Kcat-value of native mAOX3, pH 7.4, 25°C
1.67
cinnamaldehyde
pH 8, 37°C
2.73
cinnamaldehyde
pH 8, 37°C
2.95
cinnamaldehyde
pH 8, 37°C
1.22
crotonaldehyde
wild-type, pH 8.0, 37°C
2.11
crotonaldehyde
pH 8, 37°C
7.76
crotonaldehyde
pH 8, 37°C
8.32
crotonaldehyde
pH 8, 37°C
1.24
ethyl vanillin
pH 8, 37°C
1.48
ethyl vanillin
pH 8, 37°C
6.35
ethyl vanillin
pH 8, 37°C
0.54
Heptanal
pH 8, 37°C
0.54
Heptanal
wild-type, pH 8.0, 37°C
0.54
hexanal
wild-type, pH 8.0, 37°C
0.04
methotrexate
pH 7.5, 37°C
84
methotrexate
pH 7.5, 37°C
0.447
N-methylnicotinamide
-
electron acceptor: cytochrome c
1.14
N-methylnicotinamide
-
electron acceptor: nitro blue tetrazolium
1.81
N-methylnicotinamide
-
electron acceptor: dichlorophenolinodphenol
1.97
N-methylnicotinamide
-
electron acceptor: ferricyanide
0.38
N1-methyl-nicotineamide
mutant F1014V, pH 8.0,37°C
0.4
N1-methyl-nicotineamide
wild-type, pH 8.0,37°C
1.08
N1-methyl-nicotineamide
mutant P1015A, pH 8.0,37°C
1.92
N1-methyl-nicotineamide
mutant P1015G, pH 8.0,37°C
0.052
N1-methylnicotinamide
K889H mutant, pH 8.0, 37°C
0.187
N1-methylnicotinamide
A807V mutant, pH 8.0, 37°C
0.245
N1-methylnicotinamide
mAOX3 wild type, pH 8.0, 37°C
0.33
N1-methylnicotinamide
pH 8, 37°C
0.39
N1-methylnicotinamide
Y885M mutant, pH 8.0, 37°C
0.45
N1-methylnicotinamide
A807V/Y885M double mutant, pH 8.0, 37°C
0.82
N1-methylnicotinamide
pH 8, 37°C
0.46
octanal
pH 8, 37°C
0.8
octanal
wild-type, pH 8.0, 37°C
0.45
pentanal
mutant V1016I, pH 8.0, 37°C
0.92
pentanal
mutant M1088V, pH 8.0, 37°C
1.11
pentanal
mutant V1016F, pH 8.0, 37°C
1.28
pentanal
mutant I1018K, pH 8.0, 37°C
2.65
pentanal
mutant I1018S, pH 8.0, 37°C
2.79
pentanal
wild-type, pH 8.0, 37°C
7.98
pentanal
mutant M1088T, pH 8.0, 37°C
0.18
phenanthridine
mutant F1014I, pH 8.0,37°C
0.862
phenanthridine
mAOX3 wild type, pH 8.0, 37°C
1.33
phenanthridine
K889H mutant, pH 8.0, 37°C
1.42
phenanthridine
mutant F1014V, pH 8.0,37°C
1.42
phenanthridine
wild-type, pH 8.0,37°C
1.96
phenanthridine
pH 8, 37°C
2.01
phenanthridine
pH 8, 37°C
2.35
phenanthridine
pH 8, 37°C
3.63
phenanthridine
A807V/Y885M double mutant, pH 8.0, 37°C
4.45
phenanthridine
Y885M mutant, pH 8.0, 37°C
5.25
phenanthridine
A807V mutant, pH 8.0, 37°C
8.83
phenanthridine
mutant P1015G, pH 8.0,37°C
9.68
phenanthridine
mutant P1015A, pH 8.0,37°C
0.47
phenylacetaldehyde
wild-type, pH 8.0, 37°C
1.99
phenylacetaldehyde
pH 8, 37°C
2.28
phenylacetaldehyde
pH 8, 37°C
4.66
phenylacetaldehyde
pH 8, 37°C
0.53
phenylpropionaldehyde
wild-type, pH 8.0, 37°C
1.35
phenylpropionaldehyde
pH 8, 37°C
1.49
phenylpropionaldehyde
pH 8, 37°C
6.32
phenylpropionaldehyde
pH 8, 37°C
0.19
Phthalazine
wild-type, 30°C, pH 7.4
0.197
Phthalazine
K889H mutant, pH 8.0, 37°C
0.22
Phthalazine
mutant V1016L, pH 8.0, 37°C
0.28
Phthalazine
mutant V1016I, pH 8.0, 37°C
0.67
Phthalazine
mutant V1016F, pH 8.0, 37°C
0.685
Phthalazine
A807V mutant, pH 8.0, 37°C
0.685
Phthalazine
mAOX3 wild type, pH 8.0, 37°C
0.69
Phthalazine
A807V/Y885M double mutant, pH 8.0, 37°C
0.815
Phthalazine
Y885M mutant, pH 8.0, 37°C
0.97
Phthalazine
mutant F1014I, pH 8.0,37°C
1.04
Phthalazine
mutant M1088V, pH 8.0, 37°C
1.1
Phthalazine
wild-type, pH 8.0,37°C
1.62
Phthalazine
pH 8, 37°C
1.72
Phthalazine
mutant V806E, 30°C, pH 7.4
1.9
Phthalazine
mutant I1018K, pH 8.0, 37°C
2.92
Phthalazine
pH 8, 37°C
2.98
Phthalazine
mutant P1015A, pH 8.0,37°C
4.12
Phthalazine
pH 8, 37°C
4.63
Phthalazine
mutant F1014V, pH 8.0,37°C
5.3
Phthalazine
mutant I1018S, pH 8.0, 37°C
5.52
Phthalazine
wild-type, pH 8.0, 37°C
5.78
Phthalazine
mutant P1015G, pH 8.0,37°C
8.73
Phthalazine
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
10.3
Phthalazine
mutant M1088T, pH 8.0, 37°C
0.66
propionaldehyde
pH 8, 37°C
1.41
propionaldehyde
wild-type, pH 8.0, 37°C
2.39
propionaldehyde
pH 8, 37°C
5.06
propionaldehyde
pH 8, 37°C
0.3
purine
wild-type, pH 8.0, 37°C
0.18
retinalaldehyde
pH 8, 37°C
0.47
retinalaldehyde
pH 8, 37°C
2.05
retinalaldehyde
pH 8, 37°C
0.022
retinaldehyde
mutant M884R, 30°C, pH 7.4
0.23
retinaldehyde
mutant V806E, 30°C, pH 7.4
0.83
retinaldehyde
wild-type, 30°C, pH 7.4
0.39
Salicylaldehyde
mutant V1016F, pH 8.0, 37°C
0.58
Salicylaldehyde
mutant V1016I, pH 8.0, 37°C
0.93
Salicylaldehyde
mutant V1016L, pH 8.0, 37°C
1.14
Salicylaldehyde
mutant M1088V, pH 8.0, 37°C
1.89
Salicylaldehyde
mutant I1018K, pH 8.0, 37°C
2.29
Salicylaldehyde
pH 8, 37°C
2.29
Salicylaldehyde
pH 8, 37°C
3.42
Salicylaldehyde
pH 8, 37°C
3.42
Salicylaldehyde
wild-type, pH 8.0, 37°C
3.55
Salicylaldehyde
pH 8, 37°C
3.55
Salicylaldehyde
pH 8, 37°C
3.69
Salicylaldehyde
pH 8, 37°C
3.7
Salicylaldehyde
pH 8, 37°C
5.12
Salicylaldehyde
mutant I1018S, pH 8.0, 37°C
11.25
Salicylaldehyde
mutant M1088T, pH 8.0, 37°C
0.26
Vanillin
pH 8, 37°C
0.26
Vanillin
wild-type, pH 8.0, 37°C
1.2.3.1 aldehyde oxidase
results (
results (
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