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1.2.1.91: 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase, go to the full flat file.

Reaction

3-oxo-5,6-dehydrosuberyl-CoA semialdehyde
+
NADP+
+
H2O
=
3-oxo-5,6-dehydrosuberyl-CoA
+
NADPH
+
H+

Synonyms

EC 1.17.1.7, oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (NADP+), paaZ, PaaZ-ALDH, PacL

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.91 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase

Systematic Name

Systematic Name on EC 1.2.1.91 - 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP+ oxidoreductase
The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 3.3.2.12, oxepin-CoA hydrolase. Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway.