1.2.1.90: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
GAPN, More, NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase, NAD+-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating Ga3PDHase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating NAD+-dependent GAPN
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Natural Substrates Products on EC 1.2.1.90 - glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
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REACTION DIAGRAM
D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O
3-phospho-D-glycerate + NAD(P)H + 2 H+
the enzyme is part of the modified glycolytic pathway of Thermoproteus tenax. In the classical EmbdenÂMeyerhofÂParnas glycolysis, as found in Eucarya and Bacteria, the oxidation of D-glyceraldehyde 3-phosphate is coupled to phosphorylation to yield 1,3-diphosphoglycerate, which in turn is utilized by phosphoglycerate kinase giving 3-phosphoglycerate and ATP. These steps are reversible and non-regulated in the common EmbdenÂMeyerhofÂParnas pathway. In contrast, the direct and irreversible oxidation of D-glyceraldehyde 3-phosphate to 3-phospho-D-glycerate without production of ATP is catalysed either by non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase or by glyceraldehyde-3-phosphate ferredoxin oxidoreductase (EC 1.2.7.6). The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase/glyceraldehyde-3-phosphate ferredoxin oxidoreductase substitution in the catabolic EmbdenÂMeyerhofÂParnas pathway avoids the production of the highly thermolabile compound 1,3-diphosphoglycerate and could minimize the pools of the thermolabile intermediates D-glyceraldehyde 3-phosphate and dihydroxyacetonphosphate by driving the carbon flow down the pathway and thus reducing the velocity of their heat destruction
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D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
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3-phospho-D-glycerate + NADH + 2 H+
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D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + 2 H+
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D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + 2 H+
part of the modified Emden-Meyerhof-Parnas pathway in Thermoproteus tenax
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D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + 2 H+
the enzyme is part of the modified EmbdenÂMeyerhofÂParnas pathway, the main route for carbohydrate metabolism in Thermoproteus tenax
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