1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase

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For detailed information about L-glutamate gamma-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

1-pyrroline dehydrogenase, aldehyde dehydrogenase 12, ALDH12, Aldh4a1, dehydrogenase, 1-pyrroline-5-carboxylate, DELTA1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, DR_0813, EC 1.5.1.12, GSAL dehydrogenase, GSALDH, l-glutamate-gamma-semialdehyde dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, LRRP Ba1-651, NAD+-dependent glutamate gamma-semialdehyde dehydrogenase, OsALDH12, OsALDH18-2, P5C dehydrogenase, P5C synthase, P5C-DH, P5CD, P5CDH, P5CDH1, P5CS, PDH, PpALDH12, proline/P5C dehydrogenase, Put2, PutA, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylic acid dehydrogenase, Tc00.1047053510943.50, YcgN, ZmALDH12

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase

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2	Activating Compound
27445	AA Sequence
3	Application
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43	Cofactor
10	Crystallization (Commentary)
30	Disease/ Diagnostics
5	Expression
12	General Information
4	General Stability
8	IC50 Value
146	Inhibitors
23	kcat/KM [mM/s]
24	Ki Value [mM]
79	KM Value [mM]
23	Localization
2	Metals/Ions
31	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
122	Organism
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65	PDB ID
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26	Protein Variants
14	Purification (Commentary)
8	Reaction
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73	Reference
52	Source Tissue
28	Specific Activity [micromol/min/mg]
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109	Substrates and Products (Substrate)
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67	Synonyms
1	Systematic Name
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7	Temperature Stability [°C]
35	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.1.88 - L-glutamate gamma-semialdehyde dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

L-glutamate gamma-semialdehyde:NAD+ oxidoreductase

This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5].