1.2.1.80: long-chain acyl-[acyl-carrier-protein] reductase
This is an abbreviated version!
For detailed information about long-chain acyl-[acyl-carrier-protein] reductase, go to the full flat file.
Word Map on EC 1.2.1.80
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1.2.1.80
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acyl-acps
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alkane
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oxygenase
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biofuels
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cyanobacterial
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aldehyde-deformylating
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synechococcus
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deformylating
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acetyl-coa
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acyl-coas
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elongatus
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pentadecane
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synechocystis
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prochlorococcus
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nostoc
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petroleum-based
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diesel
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petroleum-derived
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punctiforme
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drug development
- 1.2.1.80
- acyl-acps
- alkane
- oxygenase
-
biofuels
-
cyanobacterial
-
aldehyde-deformylating
- synechococcus
-
deformylating
- acetyl-coa
- acyl-coas
- elongatus
- pentadecane
- synechocystis
- prochlorococcus
- nostoc
-
petroleum-based
-
diesel
-
petroleum-derived
- punctiforme
- drug development
Reaction
Synonyms
AAR, acyl-ACP reductase, acyl-acyl carrier protein (acyl-ACP) reductase, acyl-acyl carrier protein reductase, AtFAR6, CpFAS1 acyl reductase, CpFAS1-R, DPW, fatty acyl-ACP reductase, fatty aldehyde-generating acyl-ACP reductase, Npun_R1710, sll0209
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Substrates Products
Substrates Products on EC 1.2.1.80 - long-chain acyl-[acyl-carrier-protein] reductase
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REACTION DIAGRAM
a long-chain aldehyde + an [acyl-carrier protein] + NAD(P)+
a long-chain acyl-[acyl-carrier protein] + NAD(P)H + H+
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fatty acyl-CoA + NAD(P)H + H+
fatty aldehyde + CoA + NAD(P)+
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CpFAS1-R can only utilize very long chain fatty acyl-CoAs as substrates, with activity on C26 > C24 > C22 > C20, but no activity on C18 and C16 or fewer carbons
since aldehydes are toxic to cells it is very likely that the fatty aldehyde is immediately transformed into the corresponding alcohol by the enzyme complex
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?
fatty acyl-[acyl carrier protein] + NAD(P)H + H+
fatty aldehyde + acyl carrier protein + NAD(P)+
fatty acyl-[acyl-carrier protein] + NAD(P)H + H+
fatty aldehyde + acyl-carrier protein + NAD(P)+
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?
hexadecanoyl-[acyl-carrier protein] + NAD(P)H + H+
hexadecanal + acyl-carrier protein + NAD(P)+
oleoyl-[acyl carrier protein] + NAD(P)H + H+
oleic aldehyde + acyl carrier protein + NAD(P)+
oleoyl-[acyl carrier protein] + NADPH + H+
oleic aldehyde + acyl carrier protein + NADP+
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?
stearoyl-[acyl carrier protein] + NADPH + H+
stearoylaldehyde + acyl carrier protein + NADP+
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stearoyl-[acyl-carrier protein] + NAD(P)H + H+
stearylaldehyde + an [acyl-carrier protein] + NAD(P)+
fatty aldehyde + acyl carrier protein + NAD(P)+
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kinetically preferred and likely the in vivo substrate
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?
fatty acyl-[acyl carrier protein] + NAD(P)H + H+
fatty aldehyde + acyl carrier protein + NAD(P)+
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kinetically preferred and likely the in vivo substrate
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?
hexadecanal + acyl-carrier protein + NAD(P)+
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acyl-CoA and acyl-ACP can serve as substrates
hexadecanal is a reaction intermediate that is further converted into hexadecanol
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hexadecanoyl-[acyl-carrier protein] + NAD(P)H + H+
hexadecanal + acyl-carrier protein + NAD(P)+
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substrate selectivity
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hexadecanoyl-[acyl-carrier protein] + NAD(P)H + H+
hexadecanal + acyl-carrier protein + NAD(P)+
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acyl-ACP is kinetically preferred and is likely the in vivo substrate
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?
hexadecanoyl-[acyl-carrier protein] + NAD(P)H + H+
hexadecanal + acyl-carrier protein + NAD(P)+
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substrate selectivity
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?
hexadecanoyl-[acyl-carrier protein] + NAD(P)H + H+
hexadecanal + acyl-carrier protein + NAD(P)+
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acyl-ACP is kinetically preferred and is likely the in vivo substrate
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?
oleic aldehyde + acyl carrier protein + NAD(P)+
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oleoyl-[acyl carrier protein] + NAD(P)H + H+
oleic aldehyde + acyl carrier protein + NAD(P)+
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?
palmitoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
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hexadecanal + acyl carrier protein + NADP+
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specific substrate
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palmitoyl-[acyl carrier protein] + NADPH + H+
hexadecanal + acyl carrier protein + NADP+
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stearoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
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stearylaldehyde + an [acyl-carrier protein] + NAD(P)+
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the enzyme specifically transfers the pro-R hydride of NADPH to the Cys294-thioester intermediate to afford its aldehyde product
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stearoyl-[acyl-carrier protein] + NAD(P)H + H+
stearylaldehyde + an [acyl-carrier protein] + NAD(P)+
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the enzyme specifically transfers the pro-R hydride of NADPH to the Cys294-thioester intermediate to afford its aldehyde product
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in Saccharomyces cerevisiae overexpressed truncated version of AtFAR6, which lacks the N-terminal extension, produces C16:0 primary fatty alcohol as well as C18:0 fatty alcohols much more efficiently than the full length protein
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additional information
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because of technical difficulties in preparing the native substrates for CpFAS1-R, which are very long chain fatty acyl-ACPs, long chain and very long chain fatty acyl-CoAs are used as substrates to assay CpFAS1-R activity
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