1.2.1.72: erythrose-4-phosphate dehydrogenase
This is an abbreviated version!
For detailed information about erythrose-4-phosphate dehydrogenase, go to the full flat file.
Word Map on EC 1.2.1.72
Reaction
Synonyms
E4P dehydrogenase, E4PD, E4PDH, epd, Epd dehydrogenase, erythrose 4-phosphate dehydrogenase, gap2, GapB, gapB-encoded dehydrogenase, GapB-encoded protein
ECTree
1.2.1.72 erythrose-4-phosphate dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.2.1.72 - erythrose-4-phosphate dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-erythrose 4-phosphate + 3-acetylpyridine adenine dinucleotide
4-phosphoerythronate + ?
-
-
-
-
?
D-ribose 5-phosphate + NAD+
? + NADH
D-Ribose 5-phosphate can be used as ketol acceptor substrate in the reaction although D-ribose 5-phosphate is also a substrate for the coupling enzyme
-
-
?
D-erythrose 4-phosphate + NAD+
4-phosphoerythronate + NADH
-
the enzyme possible plays a role in the de novo biosynthesis of pyridoxal 5'-phosphate
-
-
?
D-erythrose 4-phosphate + NAD+
4-phosphoerythronate + NADH
-
the chemical mechanism of erythrose 4-phosphate oxidation by gap-encoded protein proceeds through a two-step mechanism involving covalent intermediates with Cys149, with rates associated to the acylation and deacylation process of 280 per s and 20 per s, respectively. No isotopic solvent effect is observed, suggesting that the rate-limiting step is not hydrolysis
-
-
?
D-erythrose 4-phosphate + NAD+
4-phosphoerythronate + NADH
production of E4P can be coupled to the NADH generating E4PD activity which enables measurement of the transketolase reaction involving F6P as donor substrate
-
-
?
additional information
?
-
-
enzyme is involved in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12
-
-
?
additional information
?
-
-
epd expression is very low in Escherichia coli. In presence of glucose, the 3 epd, pgk and fba ORFs are efficiently cotranscribed from promoter epd P0. Translational limitation of the epd expression in Escherichia coli
-
-
?
additional information
?
-
-
gapB is dispensable for glycolysis and pyridoxal biosynthesis pathway
-
-
?
additional information
?
-
-
the enzyme also shows low phosphorylating glyceraldehyde-3-phosphate dehydrogenase activity
-
-
?
additional information
?
-
fructose 6-phosphate, glycerol 6-phosphate and glyceraldehyde 3-phosphate can not be used as substrate by E4PD when added up to 50 mM
-
-
?
additional information
?
-
-
expression of epd in Vibrio cholera is not regulated by iron, nor is it required for virulence in an infant model
-
-
?
