1.2.1.70: glutamyl-tRNA reductase

This is an abbreviated version!
For detailed information about glutamyl-tRNA reductase, go to the full flat file.

Reaction

Synonyms

AtHEMA1, EC 2.7.2.13, GluRS, glutamate tRNA reductase, glutamate-specific tRNA reductase, glutamyl transfer RNA reductase, glutamyl-tRNA reductase, GluTR, GluTR1, GTR, GtrR, hemA, HEMA1, HEMA2, reductase, glutamyl-transfer ribonucleate, ZjGluTR

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.70 glutamyl-tRNA reductase

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Results	in table
9	Activating Compound
28795	AA Sequence
4	Application
1	CAS Registry Number
20	Cloned(Commentary)
43	Cofactor
4	Crystallization (Commentary)
8	Expression
20	General Information
2	General Stability
3	IC50 Value
47	Inhibitors
2	KM Value [mM]
12	Localization
5	Metals/Ions
22	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
62	Organism
7	Pathway
9	PDB ID
3	pH Optimum
2	pI Value
39	Protein Variants
17	Purification (Commentary)
1	Reaction
52	Reference
27	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
62	Substrates and Products (Substrate)
17	Subunits
59	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.1.70 - glutamyl-tRNA reductase

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SYSTEMATIC NAME

IUBMB Comments

L-glutamate-semialdehyde:NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)

This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.