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1.2.1.61: 4-hydroxymuconic-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about 4-hydroxymuconic-semialdehyde dehydrogenase, go to the full flat file.

Reaction

4-hydroxymuconic semialdehyde
+
NAD+
+
H2O
=
maleylacetate
+
NADH
+
H+

Synonyms

4-HS dehydrogenase, 4-hydroxymuconic semialdehyde dehydrogenase, gamma-hydroxymuconic semialdehyde dehydrogenase, hAPE, HqdC, NAD dependent gamma-hydroxymuconic semialdehyde dehydrogenase, PdcG, pnpE

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.61 4-hydroxymuconic-semialdehyde dehydrogenase

General Information

General Information on EC 1.2.1.61 - 4-hydroxymuconic-semialdehyde dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
the pnpE-encoded enzyme gamma-hydroxymuconic semialdehyde dehydrogenase catalyzes the reduction of 4-hydroxymuconic semialdehyde to maleylacetate in Pseudomonas sp. strain WBC-3, playing a key role in the catabolism of toxic para-nitrophenol to Krebs cycle intermediates
additional information
highly conserved residues C281 and E247 are identified to be critical for its catalytic activity, and flexible docking studies of the enzyme-substrate system predict the interactions between PnpE and its substrate 4-hydroxymuconic semialdehyde, flexible docking of substrate to PnpE, molecular docking analysis, overview