1.2.1.61: 4-hydroxymuconic-semialdehyde dehydrogenase
This is an abbreviated version!
For detailed information about 4-hydroxymuconic-semialdehyde dehydrogenase, go to the full flat file.
Reaction
Synonyms
4-HS dehydrogenase, 4-hydroxymuconic semialdehyde dehydrogenase, gamma-hydroxymuconic semialdehyde dehydrogenase, hAPE, HqdC, NAD dependent gamma-hydroxymuconic semialdehyde dehydrogenase, PdcG, pnpE
ECTree
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General Information
General Information on EC 1.2.1.61 - 4-hydroxymuconic-semialdehyde dehydrogenase
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metabolism
physiological function
the pnpE-encoded enzyme gamma-hydroxymuconic semialdehyde dehydrogenase catalyzes the reduction of 4-hydroxymuconic semialdehyde to maleylacetate in Pseudomonas sp. strain WBC-3, playing a key role in the catabolism of toxic para-nitrophenol to Krebs cycle intermediates
additional information
highly conserved residues C281 and E247 are identified to be critical for its catalytic activity, and flexible docking studies of the enzyme-substrate system predict the interactions between PnpE and its substrate 4-hydroxymuconic semialdehyde, flexible docking of substrate to PnpE, molecular docking analysis, overview
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enzyme is part of the degradation pathway of 4-nitrophenol which is a priority environmental pollutant
metabolism
HqdC gene is part of a gene cluster associated with hydroquinone degradation into 3-oxoadipate
metabolism
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enzyme is part of the degradation pathway of 4-nitrophenol which is a priority environmental pollutant
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metabolism
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HqdC gene is part of a gene cluster associated with hydroquinone degradation into 3-oxoadipate
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