1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

2-ketoaldehyde dehydrogenase, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP-dependent alpha-ketoaldehyde dehydrogenase, NADP-linked alpha-ketoaldehyde dehydrogenase

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)

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Results	in table
14	Activating Compound
2	CAS Registry Number
1	Cloned(Commentary)
17	Cofactor
11	Inhibitors
19	KM Value [mM]
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
4	pH Optimum
6	pH Range
1	pH Stability
7	Purification (Commentary)
1	Reaction
3	Reaction Type
11	Reference
13	Source Tissue
6	Specific Activity [micromol/min/mg]
3	Storage Stability
28	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name

Purification

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Purification on EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP+)

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2 entries

using acetone powder extract, ammonium sulfate fractionation, alumina C-gamma gel and column chromatography on Sephadex G-200

Ovis aries

288146

using ammonium sulfate fractionation and chromatography on DEAE-Sephadex A-50 column, Blue-dextran affinity column and CM-Sephadex C-50 column

Rattus norvegicus

288256

using ammonium sulfate fractionation and chromatography on DEAE-Sephadex column, Blue-dextran affinity column and CM-Sephadex column

Rattus norvegicus

288259

using ammonium sulfate fractionation, column chromatography on DEAE-cellulose, phosphocellulose, Sephadex G-200, hydroxylapatite, and DEAE-cellulose

Ovis aries

288143

using treatment with acetone, ammonium sulfate fractionation, and gel filtration on Sephadex G-25

Ovis aries

288145