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1.2.1.36: retinal dehydrogenase

This is an abbreviated version!
For detailed information about retinal dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.36

Reaction

retinal
+
NAD+
+
H2O
=
retinoate
+
NADH
+
H+

Synonyms

aldehyde dehydrogenase 1, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A2, aldehyde dehydrogenase 1A3, ALDH 1A1, ALDH 1A2, ALDH class 1, ALDH-1A1, ALDH-3A1, ALDH1, ALDH1A1, Aldh1a2, Aldh1a3, BcALDH, cytosolic retinal dehydrogenase, dehydrogenase, retinal, dehydrogenase/reductase member 3, DHRS3, ETA-crystallin, More, NAD+-dependent aldehyde dehydrogenase, NAD-dependent retinal dehydrogenase, NAD-dependent retinal dehydrogenases, PB-RALDH, phenobarbital-induced aldehyde dehydrogenase, RALDH, RALDH-1, RALDH-3, RalDH1, RALDH1A1, RALDH2, RALDH3, Raldh4, RDH12, RDH13, RDH5, retialdehyde dehydrogenase, Retinal dehydrogenase, retinal dehydrogenase 1, retinal dehydrogenase 2, retinal dehydrogenase 3, retinal dehydrogenase 4, retinal dehydrogenase 5, retinal dehydrogenase type-2, retinal dehydrogenase-2, retinal dehydrogenase/reductase, retinal short-chain dehydrogenase/reductase, retinalaldehyde dehydrogenase 2, retinaldehyde dehydrogenase, retinaldehyde dehydrogenase 1, retinaldehyde dehydrogenase 2, retinaldehyde dehydrogenase 3, retinaldehyde dehydrogenase type II, retinaldehyde dehydrogenase type-1, retinaldehyde dehydrogenase-2, retinaldehyde dehydrogenases, retinol dehydrogenase 13, retSDR1, testis-specific aldehyde dehydrogenase, thyroid-hormone-binding protein, type 2 retinaldehyde dehydrogenase, xCTBP, xCTBP/xALDH1, zRalDH

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.36 retinal dehydrogenase

Engineering

Engineering on EC 1.2.1.36 - retinal dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C302A
site-directed mutagenesis of catalytic active center residue, the mutant ALDH1A1 loses both activities
C303A
site-directed mutagenesis of catalytic active center residue, the mutant ALDH1A1 loses both activities
C456A
site-directed mutagenesis of a cysteine residue outside the active center, the mutation has no effect on both the aldehyde-dehydrogenase activity and the GSH/DHLA-dependent NAD+-reduction activity
E107G
site-directed mutagenesis, mutation of a residue that contributes to conformational integrity, the mutant loses its aldehyde-dehydrogenase activity, yet completely retains its GSH/DHLA-dependent NAD+-reduction activity
G246A/G251A
site-directed mutagenesis of NAD+-binding sites, the mutant ALDH1A1 loses both the aldehyde-dehydrogenase activity and the GSH/DHLA-dependent NAD+-reduction activity
I304K
site-directed mutagenesis, the mutant loses its aldehyde-dehydrogenase activity
K127A
N120A
W178E/I304K
site-directed mutagenesis, mutation of aldehyde binding residues W178 and I304, the mutant loses its aldehyde-dehydrogenase activity, yet completely retains its GSH/DHLA-dependent NAD+-reduction activity
Y296A
Y296V
C301A
-
site-directed mutagenesis, catalytic residue mutation, reduced activity compared to the wild-type enzyme
F471L
mutant
L459F/N460G
-
site-directed mutagenesis, inactive mutant, still able to bind the cofactor NAD+
T1411C
mutant
additional information