1.2.1.30: carboxylate reductase (NADP+)

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For detailed information about carboxylate reductase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.30

1.2.1.30

synthesis

bio-based

fragrance

autoinduction

phosphopantetheinylation

over-reduction

benzaldehyde

industry

Reaction

Synonyms

aromatic acid reductase, aryl aldehyde:NADP+ oxidoreductase, aryl-aldehyde dehydrogenase (NADP+), aryl-aldehyde oxidoreductase, ATP/NADPH-dependent carboxylic acid reductase, CAR, carboxylate reductase, carboxylate reductases, Carboxylic acid reductase, kaCAR, mab3CAR, maCAR, mmCAR, mpCAR, msCAR, naCAR, NcCAR, niCAR, noCAR, tpCAR, type I CAR, type III CAR

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.30 carboxylate reductase (NADP+)

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Results	in table
11	Activating Compound
9	AA Sequence
37	Application
1	CAS Registry Number
22	Cloned(Commentary)
81	Cofactor
93	General Information
1	General Stability
43	Inhibitors
84	kcat/KM [mM/s]
6	Ki Value [mM]
100	KM Value [mM]
25	Metals/Ions
6	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
75	Organism
3	PDB ID
14	pH Optimum
1	pH Range
1	pI Value
22	Posttranslational Modification
84	Protein Variants
12	Purification (Commentary)
36	Reaction
3	Reaction Type
61	Reference
4	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
294	Substrates and Products (Substrate)
25	Subunits
137	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
77	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.2.1.30 - carboxylate reductase (NADP+)

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AMP

12 entries

anthranilic acid

Nocadia sp.

competitive inhibitor with benzoic acid as a substrate

288184

diphosphate

11 entries

hydroxylamine

Neurospora crassa

inhibition of the exchange reaction of diphosphate and ATP

288180

iodoacetamide

Neurospora crassa

inhibition of the reduction of benzoyladenosine 5'-monophosphate, even in the presence of dithiothreitol

288180

iodoacetate

Neurospora crassa

inhibition of the reduction of benzoyladenosine 5'-monophosphate, even in the presence of dithiothreitol

288180

N-ethylmaleimide

Neurospora crassa

inhibition of the reduction of benzoyladenosine 5'-monophosphate

288180

NADP+

11 entries

NADPH

Neurospora crassa

inhibition of the exchange reaction of diphosphate and ATP, inhibitory effect increases when dithiothreitol is added

288180

o-Iodosobenzoate

Neurospora crassa

inhibition of the reduction of benzoyladenosine 5'-monophosphate, even in the presence of dithiothreitol

288180

p-chloromercuribenzoate

Neurospora crassa

inhibition of the reduction of benzoyladenosine 5'-monophosphate, even in the presence of dithiothreitol

288180

p-diazobenzenesulfonate

Neurospora crassa

inhibition of the reduction of benzoyladenosine 5'-monophosphate, even in the presence of dithiothreitol

288180