1.2.1.3: aldehyde dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.2.1.3
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1.2.1.3
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aldhs
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retinoic
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metastasis
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self-renewal
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isozymes
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stem-like
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smoke
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esophageal
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drinker
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nanog
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flush
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myocardial
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east
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retinaldehyde
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tumorigenic
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clinicopathological
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case-control
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smoking
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colorectal
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epithelial-mesenchymal
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cyp2e1
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chemoresistance
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spheroid
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alcohol-induced
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disulfiram
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mesenchymal
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alcohol-related
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sphere
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detoxify
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habit
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nitroglycerin
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cell-like
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4-hydroxy-2-nonenal
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tumor-initiating
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trinitrate
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mammosphere
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keratocytes
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csc-like
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sphere-forming
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cyanamide
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aerodigestive
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non-drinkers
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epcam
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glyceryl
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alcohol-dependent
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tumorsphere
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chloral
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analysis
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dehydrogenase-1
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synthesis
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low-km
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medicine
-
ichthyosis
- 1.2.1.3
-
aldhs
-
retinoic
- metastasis
-
self-renewal
- isozymes
-
stem-like
-
smoke
- esophageal
-
drinker
-
nanog
-
flush
- myocardial
-
east
- retinaldehyde
-
tumorigenic
-
clinicopathological
-
case-control
-
smoking
- colorectal
-
epithelial-mesenchymal
- cyp2e1
-
chemoresistance
-
spheroid
-
alcohol-induced
- disulfiram
- mesenchymal
-
alcohol-related
-
sphere
-
detoxify
-
habit
- nitroglycerin
-
cell-like
- 4-hydroxy-2-nonenal
-
tumor-initiating
- trinitrate
-
mammosphere
- keratocytes
-
csc-like
-
sphere-forming
- cyanamide
-
aerodigestive
-
non-drinkers
- epcam
-
glyceryl
-
alcohol-dependent
-
tumorsphere
- chloral
- analysis
-
dehydrogenase-1
- synthesis
-
low-km
- medicine
- ichthyosis
Reaction
Synonyms
ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALD6, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 16, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 1B1, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde dehydrogenase 6, aldehyde dehydrogenase 7A1, aldehyde dehydrogenase class 1, aldehyde dehydrogenase type 2, Aldehyde dehydrogenase [NAD+], Aldehyde dehydrogenase, cytosolic, Aldehyde dehydrogenase, microsomal, aldehyde dehydrogenase-2, aldehyde dehydrogenase7, aldehyde:NAD+ oxidoreductase, ALDH, ALDH 2, ALDH I, ALDH II, ALDH-2, ALDH-E1, ALDH-E2, ALDH1, ALDH1-NL, ALDH16, ALDH1A1, Aldh1a2, Aldh1a3, Aldh1a7, Aldh1b1, ALDH2, ALDH2(1), ALDH2(2), ALDH2(3), ALDH22A1, ALDH2B8, ALDH2C4, ALDH3A1, ALDH3A2, Aldh3b1, ALDH3H1, ALDH3I1, ALDH5A, ALDH7, Aldh7a1, ALDH7B4, Aldh8a1, ALDHI, ALDHTt, ALDHX, ALHDII, Allergen Alt a 10, aryl-aldehyde dehydrogenases, BADH, benzaldehyde dehydrogenase, Brassica turgor-responsive/drought-induced gene 26 protein, Bt-Aldh, Btg-26, class 1 aldehyde dehydrogenase, class 2 aldehyde dehydrogenase, class I ALDH, CoA-independent aldehyde dehydrogenase, coniferyl-aldehyde dehydrogenase, Cphy_1178, EC 1.1.1.70, ETA-crystallin, FeaB-K-12, gamma-aminobutyraldehyde dehydrogenase, hALDH2, HsALDH16A1, irreversible NAD+-dependent aldehyde dehydrogenase, K(+)-ACDH, K(+)-activated acetaldehyde dehydrogenase, KGSADH, LsALDH16, m-methylbenzaldehyde dehydrogenase, Matured fruit 60 kDa protein, MF-60, Mg(2+)-ACDH, Mg(2+)-activated acetaldehyde dehydrogenase, mitochondrial aldehyde dehydrogenase, More, NAD+-dependent aldehyde dehydrogenase, NAD+-dependent ALDH, NAD+-linked aldehyde dehydrogenase, NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase, NAD+-specific ALDH, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, Non-lens ALDH1, p-ALDH2, P51, phenylacetaldehyde dehydrogenase, PhnN, phnY, phosphonoacetaldehyde dehydrogenase, phosphonoacetaldehyde oxidase, PM-ALDH9, PnAA dehydrogenase, propionaldehyde dehydrogenase, PuuC, R-aminobutyraldehyde dehydrogenase, RALDH, RALDH(II), RalDH1, Retinal dehydrogenase, retinal dehydrogenase type I, sALDH, salvery aldehyde dehydrogenase, ThnG, TTC0513, Turgor-responsive protein 26G, yALDH, YneI
ECTree
1.2.1.3 aldehyde dehydrogenase (NAD+)Advanced search results
results (
results (Turnover Number
Turnover Number on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.039
(R)-trans-4-hydroxy-2-nonenal
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37°C
0.04
(S)-trans-4-hydroxy-2-nonenal
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37°C
0.26
3-hydroxypropionic acid
-
with NADH as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
1.5
3-oxopropyl phosphonate
wild type enzyme, at pH 7.5 and 30°C
0.83
DL-glyceraldehyde 3-phosphate
-
in 50 mM Tris/HCl, at pH 8.0 and 80°C
0.04
glutathione-4-oxonon-2-enal
-
50 mM sodium phosphate buffer pH 7.4, 1 mM NAD+, 37°C
27.31
Isovaleraldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
26.24
Valeraldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
4.91
3-hydroxypropionaldehyde
-
with NADP+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
28.54
3-hydroxypropionaldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
0.26
acetaldehyde
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37°C
3.5
acetaldehyde
ALDH5A, in 40 mM sodium phosphate buffer (pH 7.4), at 37°C
11.03
acetaldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
0.3
alpha-aminoadipate semialdehyde
-
pH 8.0, 26°C, recombinant wild-type enzyme
0.0425
benzaldehyde
-
at 25°C and pH 8.5, with NADP+ as the electron acceptor
0.137
benzaldehyde
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at 25°C and pH 8.5, with NAD+ as the electron acceptor
17.37
benzaldehyde
-
with NADP+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
26.95
Butyraldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
0.098
glyceraldehyde 3-phosphate
wild type enzyme, at pH 7.5 and 30°C
0.6
NAD+
-
with DL-glyceraldehyde as cosubstrate, in 50 mM Tris/HCl, at pH 8.0 and 80°C
1.8
NAD+
mutant enzyme E149T/V178R/I200V, with trans-2-hexenal as cosubstrate, at pH 8.0 and 25°C
2.05
NAD+
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with acetaldehyde as cosubstrate, in 50 mM Tris/HCl, at pH 8.0 and 80°C
2.2
NAD+
mutant enzyme E149T/I200V, with trans-2-nonenal as cosubstrate, at pH 8.0 and 25°C
3.1
NAD+
mutant enzyme E149T/I200V, with trans-2-hexenal as cosubstrate, at pH 8.0 and 25°C
4
NAD+
mutant enzyme E149T/V178R/I200V, with trans-2-nonenal as cosubstrate, at pH 8.0 and 25°C
10.2
NAD+
mutant enzyme E149T, with hexanal as cosubstrate, at pH 8.0 and 25°C
10.7
NAD+
mutant enzyme E149D, with hexanal as cosubstrate, at pH 8.0 and 25°C
11.4
NAD+
mutant enzyme E149Q/I200V, with hexanal as cosubstrate, at pH 8.0 and 25°C
12.2
NAD+
mutant enzyme E149T/V178R/I200V, with hexanal as cosubstrate, at pH 8.0 and 25°C
12.4
NAD+
mutant enzyme E149D/I200V, with hexanal as cosubstrate, at pH 8.0 and 25°C
12.7
NAD+
mutant enzyme E149Q, with hexanal as cosubstrate, at pH 8.0 and 25°C
12.7
NAD+
mutant enzyme E149T/V178R/I200V, with nonanal as cosubstrate, at pH 8.0 and 25°C
13.1
NAD+
mutant enzyme E149N/I200V, with hexanal as cosubstrate, at pH 8.0 and 25°C
15.7
NAD+
mutant enzyme E149T/I200V, with hexanal as cosubstrate, at pH 8.0 and 25°C
16.3
NAD+
mutant enzyme I200G, with hexanal as cosubstrate, at pH 8.0 and 25°C
16.6
NAD+
mutant enzyme E149N, with hexanal as cosubstrate, at pH 8.0 and 25°C
17.2
NAD+
wild type enzyme, with hexanal as cosubstrate, at pH 8.0 and 25°C
18
NAD+
mutant enzyme E149T/I200V, with nonanal as cosubstrate, at pH 8.0 and 25°C
18.5
NAD+
mutant enzyme I200V, with hexanal as cosubstrate, at pH 8.0 and 25°C
20.1
NAD+
mutant enzyme E149Q/I200G, with hexanal as cosubstrate, at pH 8.0 and 25°C
23.2
NAD+
mutant enzyme E149D/I200G, with hexanal as cosubstrate, at pH 8.0 and 25°C
26.9
NAD+
mutant enzyme E149N/I200G, with hexanal as cosubstrate, at pH 8.0 and 25°C
33.9
NAD+
mutant enzyme E149T/I200G, with hexanal as cosubstrate, at pH 8.0 and 25°C
1.63
NADP+
-
with DL-glyceraldehyde as cosubstrate, in 50 mM Tris/HCl, at pH 8.0 and 80°C
3.71
NADP+
-
with acetaldehyde as cosubstrate, in 50 mM Tris/HCl, at pH 8.0 and 80°C
0.01
phosphonoacetaldehyde
mutant enzyme N158A, with NAD+ in 50 mM HEPES, pH 7.5 supplemented with 10 mM MgSO4 for 5 min at 30°C
0.01
phosphonoacetaldehyde
mutant enzyme N158A, at pH 7.5 and 30°C
0.051
phosphonoacetaldehyde
mutant enzyme R108A, with NAD+ in 50 mM HEPES, pH 7.5 supplemented with 10 mM MgSO4 for 5 min at 30°C
0.051
phosphonoacetaldehyde
mutant enzyme R108A, at pH 7.5 and 30°C
0.076
phosphonoacetaldehyde
mutant enzyme R447A, with NAD+ in 50 mM HEPES, pH 7.5 supplemented with 10 mM MgSO4 for 5 min at 30°C
0.076
phosphonoacetaldehyde
mutant enzyme R447A, at pH 7.5 and 30°C
0.12
phosphonoacetaldehyde
mutant enzyme R290A, with NAD+ in 50 mM HEPES, pH 7.5 supplemented with 10 mM MgSO4 for 5 min at 30°C
0.12
phosphonoacetaldehyde
mutant enzyme R290A, at pH 7.5 and 30°C
0.19
phosphonoacetaldehyde
mutant enzyme E385A, with NAD+ in 50 mM HEPES, pH 7.5 supplemented with 10 mM MgSO4 for 5 min at 30°C
0.19
phosphonoacetaldehyde
mutant enzyme E385A, at pH 7.5 and 30°C
2.2
phosphonoacetaldehyde
wild type enzyme, with NAD+ in 50 mM HEPES, pH 7.5 supplemented with 10 mM MgSO4 for 5 min at 30°C
0.42
propanal
50 mM sodium phosphate buffer, pH 7.4, 0.25 mM Mg2+,1 mM NAD+, 25°C
0.65
propanal
50 mM sodium phosphate buffer, pH 7.4, 0.2 mM Mg2+,1 mM NAD+, 25°C
6.16
propanal
50 mM sodium phosphate buffer, pH 7.4, 0.2 mM Mg2+,1 mM NAD+, 25°C
24.35
propionaldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
1.1
trans-2-hexenal
mutant enzyme E149T/V178R/I200V, at pH 8.0 and 25°C
3.8
trans-2-nonenal
mutant enzyme E149T/V178R/I200V, at pH 8.0 and 25°C
additional information
additional information
-
turnover numbers of the 475 and 264 arginine mutants of Oriental variant E847K
-
additional information
propanal
50 mM sodium phosphate buffer, pH 7.4, 0.2 mM Mg2+,1 mM NAD+, 25°C
additional information
propanal
-
50 mM sodium phosphate buffer, pH 7.4, 0.2 mM Mg2+,1 mM NAD+, 25°C
