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1.2.1.3: aldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.3

Reaction

an aldehyde
+
NAD+
 +
H2O
=
a carboxylate
 +
NADH
 +
H+

Synonyms

ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALD6, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 16, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 1B1, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde dehydrogenase 6, aldehyde dehydrogenase 7A1, aldehyde dehydrogenase class 1, aldehyde dehydrogenase type 2, Aldehyde dehydrogenase [NAD+], Aldehyde dehydrogenase, cytosolic, Aldehyde dehydrogenase, microsomal, aldehyde dehydrogenase-2, aldehyde dehydrogenase7, aldehyde:NAD+ oxidoreductase, ALDH, ALDH 2, ALDH I, ALDH II, ALDH-2, ALDH-E1, ALDH-E2, ALDH1, ALDH1-NL, ALDH16, ALDH1A1, Aldh1a2, Aldh1a3, Aldh1a7, Aldh1b1, ALDH2, ALDH2(1), ALDH2(2), ALDH2(3), ALDH22A1, ALDH2B8, ALDH2C4, ALDH3A1, ALDH3A2, Aldh3b1, ALDH3H1, ALDH3I1, ALDH5A, ALDH7, Aldh7a1, ALDH7B4, Aldh8a1, ALDHI, ALDHTt, ALDHX, ALHDII, Allergen Alt a 10, aryl-aldehyde dehydrogenases, BADH, benzaldehyde dehydrogenase, Brassica turgor-responsive/drought-induced gene 26 protein, Bt-Aldh, Btg-26, class 1 aldehyde dehydrogenase, class 2 aldehyde dehydrogenase, class I ALDH, CoA-independent aldehyde dehydrogenase, coniferyl-aldehyde dehydrogenase, Cphy_1178, EC 1.1.1.70, ETA-crystallin, FeaB-K-12, gamma-aminobutyraldehyde dehydrogenase, hALDH2, HsALDH16A1, irreversible NAD+-dependent aldehyde dehydrogenase, K(+)-ACDH, K(+)-activated acetaldehyde dehydrogenase, KGSADH, LsALDH16, m-methylbenzaldehyde dehydrogenase, Matured fruit 60 kDa protein, MF-60, Mg(2+)-ACDH, Mg(2+)-activated acetaldehyde dehydrogenase, mitochondrial aldehyde dehydrogenase, More, NAD+-dependent aldehyde dehydrogenase, NAD+-dependent ALDH, NAD+-linked aldehyde dehydrogenase, NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase, NAD+-specific ALDH, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, Non-lens ALDH1, p-ALDH2, P51, phenylacetaldehyde dehydrogenase, PhnN, phnY, phosphonoacetaldehyde dehydrogenase, phosphonoacetaldehyde oxidase, PM-ALDH9, PnAA dehydrogenase, propionaldehyde dehydrogenase, PuuC, R-aminobutyraldehyde dehydrogenase, RALDH, RALDH(II), RalDH1, Retinal dehydrogenase, retinal dehydrogenase type I, sALDH, salvery aldehyde dehydrogenase, ThnG, TTC0513, Turgor-responsive protein 26G, yALDH, YneI

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.3 aldehyde dehydrogenase (NAD+)

Cloned

Cloned on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Aldh3a1 promoter fragments are constructed and subcloned into the pGL3 basic vector
-
expressed in Arabidopsis thaliana
expressed in Escherichia coli BL21 (DE3) cells
expressed in Escherichia coli BL21 (DE3) pLysS cells
expressed in Escherichia coli BL21 cells
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3) cells (strain SH-KAD2)
-
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
-
expressed in Escherichia coli C41 cells
-
expressed in Escherichia coli coli strain BL21(DE3)pLysS
-
expressed in Escherichia coli ER2566 cells
-
expressed in Escherichia coli K-562 and H-1299 cells
expressed in Escherichia coli M15 (pREP4) cells
-
expressed in Escherichia coli Rosetta 2 (DE3) cells
expressed in Escherichia coli Rosetta2 cells
expressed in Escherichia coli strains LL346 and LL1040
expressed in Escherichia coli XL-1 cells
expressed in HeLa, Hep-G2 and JTC-12 cells
-
expressed in in Sf9 insect cells and in Mus musculus (highest human ALDH1B1 mRNA expression is detected in liver and part of the small intestine, moderate levels in the testis, distal colon, lung, heart, and duodenum and the lowest levels are found in the kidney and stomach)
-
expressed in Klebsiella pneumoniae strain DSM 2026
-
expressed in Klebsiella pneumoniae strain DSM2026
expressed in Klebsielle pneumoniae
-
expressed in Mus musculus
-
expressed in PCI-13 and SCCHN cell lines
-
expressed in Salmonella typhimurium strain TA100
-
expressed in Sf9 insect cells, in CHO cells, in human renal proximal tubular epithelial (HK-2) cells, and in Escherichia coli BL21(DE3) cells
-
expression by a baculovirus system
expression in Escherichia coli
expression in Escherichia coli BL21 (DE3) as GST fusion protein
-
expression in Escherichia coli JM109
expression in Escherichia coli. Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli
-
expression in Spodoptera frugiperda cells
expression of the dhaB gene in Escherichia coli BL21(DE3)
-
gene ALD6, functional recombinant overexpression of C-terminally GFP-tagged enzyme from vector pYES2 under control of GAL1 promoter in Saccharomyces cerevisiae strain MBTL-SYL-1 in cytosol
gene ALDH16, recombinant expression of His6-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3) Codon Plus
-
gene TTC0513, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21 Star (DE3)
into the vector pET28a for expression in Escherichia coli BL21DE3 cells
-
into the vector pT7.7 for expression in Escherichia coli BL21DE3 cells
-
mutant enzymes expressed in Escherichia coli
-
recombinant expression of wild-type and mutant enzymes in Escherichia coli
-
the GFP-tagged enzyme is expressed in Escherichia coli BL21(DE3) pLysS cells
-
when expressed in Escherichia coli M15 most of the protein is localised in inclusion bodies, not used for the enzyme assays