1.2.1.27: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
This is an abbreviated version!
For detailed information about methylmalonate-semialdehyde dehydrogenase (CoA-acylating), go to the full flat file.
Word Map on EC 1.2.1.27
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1.2.1.27
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lysosomotropic
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3-hydroxyisobutyrate
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coa-dependent
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mississippi
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propionyl-coa
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aldh6a1
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3-hydroxypropionic
- 1.2.1.27
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lysosomotropic
- 3-hydroxyisobutyrate
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coa-dependent
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mississippi
- propionyl-coa
- aldh6a1
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3-hydroxypropionic
Reaction
Synonyms
Aldh6a1, dddC, FG99_15390, KES23460, malonate-semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase protein, methylmalonate-semialdehyde dehydrogenase, methylmalonic acid semialdehyde dehydrogenase, MGG_01606, MMSADH, MMSDH, MoMSDH, MSDH, NAD-dependent malonate-semialdehyde dehydrogenase, OdoMMSDH, OsALDH6, PA3570, SSO1218
ECTree
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Turnover Number on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
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additional information
additional information
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Kcat-value of CoA for R301L mutant enzyme under steady-state conditions with propionaldehyde is above 3 1/sec at pH 8.2 and 30°C
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1.1
2-Methyl-3-oxopropanoate
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50 mM potassium phosphate pH 8.2, 30°C, 0.5 mM 2-methyl-3-oxopropanoate, 12 mM NAD+, 0.5 mM CoA
2.8
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R124L mutant enzyme, steady-state conditions with propionaldehyde, pH 8.2 and 30°C
12.6
CoA
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wild type MSDH, steady-state conditions with propionaldehyde, pH 8.2 and 30°C
0.06
NAD+
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R124L mutant enzyme, steady-state conditions with methylmalonate semialdehyde, pH 8.2 and 30°C
0.14
NAD+
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R301L mutant enzyme, steady-state conditions with methylmalonate semialdehyde, pH 8.2 and 30°C
2.2
NAD+
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wild type MSDH, steady-state conditions with methylmalonate semialdehyde, pH 8.2 and 30°C