1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

aldehyde dehydrogenase 5a1, ALDH5A, ALDH5A1, alphaKGSA dehydrogenase, dehydrogenase, succinate semialdehyde, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSADH-I, SSADH/ALDH5A1, SSALDH, SSO1629, succinate semialdehyde dehydrogenase, succinate semialdehyde:NAD+ oxidoreductase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, YneI dehydrogenase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)

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Results	in table
11	Activating Compound
2490	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
76	Cofactor
2	Crystallization (Commentary)
122	Disease/ Diagnostics
2	Expression
15	General Information
3	General Stability
6	IC50 Value
103	Inhibitors
3	kcat/KM [mM/s]
10	Ki Value [mM]
119	KM Value [mM]
15	Localization
1	Metals/Ions
42	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
124	Organism
2	Oxidation Stability
11	Pathway
9	PDB ID
20	pH Optimum
9	pH Range
5	pH Stability
1	pI Value
67	Protein Variants
20	Purification (Commentary)
5	Reaction
3	Reaction Type
82	Reference
63	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
197	Substrates and Products (Substrate)
24	Subunits
110	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
6	Temperature Stability [°C]
7	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-15°C, 14 h, 95% residual activity

Escherichia coli K-12

-

707580

-20°C, 20 mM sodium diphosphate buffer, pH 7.2, 14 mM 2-mercaptoethanol, 25% v/v glycerol, 2-3 months, retains 80-85% of the activity

Solanum tuberosum

-

288150

-20°C, in presence of 10% v/v glycerol, stable for several months

Rattus norvegicus

-

288158

-20°C, purified native enzyme, 100 mM diphosphate, pH 8.0, 14 mM 2-mercaptoethanol, 20% glycerol, loss of 50% activity witin 5 days

Aspergillus niger

A2R4V5

742640

0-2°C, 24 h, 50% loss of activity

Solanum tuberosum

-

288150

0°C, 100 mM sodium phosphate, pH 8.5, 1mM DTT, 43% glycerol, 3 years

Drosophila melanogaster

Q9VBP6

692615

18°C, 14 h, 93% residual activity

Escherichia coli K-12

-

707580

5°C, unstable unless 30% glycerol is added

Euglena gracilis

-

288042