1.2.1.16: succinate-semialdehyde dehydrogenase [NAD(P)+]

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For detailed information about succinate-semialdehyde dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.2.1.16

1.2.1.16

gamma-aminobutyric

seizure

neurotransmitter

transaminase

gamma-hydroxybutyric

4-hydroxybutyric

aldh5a1

epilepsy

shunt

aciduria

subdural

hematoma

gabaergic

ssadhd

hypotonia

gaba-transaminase

gaba-t

4-aminobutyrate

vigabatrin

neurometabolic

globus

tonic-clonic

pallidi

2.6.1.19

hyperintensities

evacuation

Reaction

Synonyms

3-sulfopropanal dehydrogenase, ALDH, BADH, BsSSADH, cce4228, cce4228 protein, dehydrogenase, succinate semialdehyde (nicotinamide adenine dinucleotide (phosphate)), gabD, GabD dehydrogenase, GabD1, gapN-2, More, NAD(P)+-coupled 3-sulfopropanal dehydrogenase, NAD(P)+-dependent benzaldehyde dehydrogenase, NAD(P)+-dependent succinate semialdehyde dehydrogenase, NAD(P)+-dependent succinic semialdehyde dehydrogenase, NAD(P)-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent SSADH, SpSSADH, SSA dehydrogenase, SSADH, SSADH-II, SSADHase, SSDH, SSO1842, ST0064, succinate semialdehyde dehydrogenase, succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), succinate-semialdehyde dehydrogenase, succinate-semialdehyde dehydrogenase (NAD(P)), succinate-semialdehyde dehydrogenase (NAD(P)+), succinic semialdehyde dehydrogenase, succinic semialdehyde:NAD(P)+ oxidoreductase, sulfopropanal dehydrogenase, YneI

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]

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Results	in table
18	Activating Compound
9051	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
64	Cofactor
4	Crystallization (Commentary)
3	Expression
13	General Information
4	General Stability
31	Inhibitors
80	kcat/KM [mM/s]
9	Ki Value [mM]
123	KM Value [mM]
8	Localization
9	Metals/Ions
21	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
681	Organism
1	Oxidation Stability
9	Pathway
47	PDB ID
16	pH Optimum
8	pH Range
4	pH Stability
48	Protein Variants
21	Purification (Commentary)
4	Reaction
4	Reaction Type
52	Reference
6	Source Tissue
78	Specific Activity [micromol/min/mg]
5	Storage Stability
147	Substrates and Products (Substrate)
18	Subunits
82	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
5	Temperature Stability [°C]
91	Turnover Number [1/s]

Engineering

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Engineering on EC 1.2.1.16 - succinate-semialdehyde dehydrogenase [NAD(P)+]

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Go to Protein Variants Search

K154A

Crocosphaera subtropica

B1WSJ7

site-directed mutagenesis, the mutant shows highly reduced activity compared to wild-type enzyme

763626

S157E

Crocosphaera subtropica

B1WSJ7

site-directed mutagenesis, the mutant shows reduced activity with NAD+/SSA and increased activity with NADP+/SSA compared to wild-type enzyme

763626

K154A

Crocosphaera subtropica BH68

site-directed mutagenesis, the mutant shows highly reduced activity compared to wild-type enzyme

S157E

Crocosphaera subtropica BH68

site-directed mutagenesis, the mutant shows reduced activity with NAD+/SSA and increased activity with NADP+/SSA compared to wild-type enzyme

C311A

Drosophila melanogaster

mutant is still soluble but unable to catalyze succinate semialdehyde oxidation. Mutation leads to an inactive product binding both succinate semialdehyde aldehyde and gem-diol

690736

C102A

Pseudomonas putida

mutant exhibits BADH activity between 50 and 75% that of the wild type enzyme

685387

C103A

Pseudomonas putida

enzyme is inactive

685387

C140A