1.2.1.11: aspartate-semialdehyde dehydrogenase
This is an abbreviated version!
For detailed information about aspartate-semialdehyde dehydrogenase, go to the full flat file.
Word Map on EC 1.2.1.11
-
1.2.1.11
-
diaminopimelate
-
aspartokinase
-
dihydrodipicolinate
-
balanced-lethal
-
beta-aspartyl
-
drug development
-
medicine
-
biotechnology
-
pharmacology
-
synthesis
- 1.2.1.11
- diaminopimelate
- aspartokinase
- dihydrodipicolinate
-
balanced-lethal
-
beta-aspartyl
- drug development
- medicine
- biotechnology
- pharmacology
- synthesis
Reaction
Synonyms
AFUA_3G06830, ASA dehydrogenase, ASA DH, ASA-DH, ASADH, ASADHD, Asd, ASD enzyme, Asd1, Asd2, AsdA, aspartate beta-semialdehyde dehydrogenase, aspartate semialdehyde dehydrogenase, aspartate-beta-semialdehyde dehydrogenase, aspartate-beta-semialdeyhyde dehydrogenase, aspartate-semialdehyde dehydrogenase, aspartic acid semialdehyde dehydrogenase, aspartic beta-semialdehyde dehydrogenase, aspartic semialdehyde dehydrogenase, aspartyl beta-semialdehyde dehydrogenase, aspartyl semialdehyde dehydrogenase, BDCG_01946, CNA02450, dehydrogenase, aspartate semialdehyde, ecASADH, FtASADH, hiASADH, L-aspartate-beta-semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosphorylating), Rv3708c
ECTree
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Reference on EC 1.2.1.11 - aspartate-semialdehyde dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shames, S.L.; Ash, D.E.; Wedler, F.C.; Villafranca, J.J.
Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli
J. Biol. Chem.
259
15331-15339
1984
Escherichia coli
Hegeman, G.D.; Cohen, G.N.; Morgan, R.
Aspartic semialdehyde dehydrogenase (Escherichia coli K12)
Methods Enzymol.
17A
708-713
1970
Escherichia coli
-
Cohen, G.N.
Aspartate-semialdehyde dehydrogenase from Escherichia coli
Methods Enzymol.
113
600-602
1985
Escherichia coli
Holland, M.J.; Westhead, E.W.
Purification and characterization of aspartic -semialdehyde dehydrogenase from yeast and purification of an isozyme of glyceraldehyde-3-phosphate dehydrogenase
Biochemistry
12
2264-2270
1973
Saccharomyces cerevisiae
Biellmann, J.F.; Eid, P.; Hirth, C.; Jörnvall, H.
Aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Purification and general properties
Eur. J. Biochem.
104
53-58
1980
Escherichia coli
Bielmann, J.F.; Eid, P.; Hirth, C.
Affinity labeling of the Escherichia coli aspartate-beta-semialdehyde dehydrogenase with an alkylating coenzyme analogue. Half-site reactivity and competition with the substrate alkylating analogue
Eur. J. Biochem.
104
65-69
1980
Escherichia coli
Biellmann, J.F.; Eid, P.; Hirth, C.; Jörnvall, H.
Aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Affinity labeling with the substrate analogue L-2-amino-4-oxo-5-chloropentanoic acid: an example of half-site reactivity
Eur. J. Biochem.
104
59-64
1980
Escherichia coli
Jenkins, M.B.; Garner, H.R.
Studies of a homoserineless bradytroph of Neurospora crassa: demonstration of an altered aspartate beta-semialdehyde dehydrogenase
Biochim. Biophys. Acta
141
287-295
1967
Neurospora crassa
Surdin, Y.
Semi-aldehyde aspartic dehydrogenase of Saccharomyces cerevisiae: properties and regulation
Eur. J. Biochem.
2
341-348
1967
Saccharomyces cerevisiae
Black, S.; Wright, N.G.
Aspartic beta-semialdehyde dehydrogenase and aspartic beta-semialdehyde
J. Biol. Chem.
213
39-50
1955
Saccharomyces cerevisiae
Thomas, D.; Surdin-Kerjan, Y.
Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression
Mol. Gen. Genet.
217
149-154
1989
Saccharomyces cerevisiae
Jagusztyn, E.K.; Malaszewska-Keough, A.; Kauc, B.
Cloning and expression of Thiobacillus versutus aspartate-semialdehyde gene in Escherichia coli
FEMS Microbiol. Lett.
59
21-26
1989
Paracoccus versutus
-
Preiss, J.; Mazelis, M.; Greenberg, E.
Cloning of the aspartate-beta-semialdehyde dehydrogenase structural gene from Escherichia coli K12
Curr. Microbiol.
7
263-268
1982
Escherichia coli
-
Jagusztyn-Krynicka, E.K.; Smorawinska, M.; Curtiss III, R.
Expression of Streptococcus mutans aspartate-semialdehyde dehydrogenase gene cloned into plasmid pBR322
J. Gen. Microbiol.
128
1135-1145
1982
Streptococcus mutans
Cremer, J.; Treptow, C.; Eggeling, L.; Sahm, H.
Regulation of enzymes of lysine biosynthesis in Corynebacterium glutamicum
J. Gen. Microbiol.
134
3221-3229
1988
Corynebacterium glutamicum
Bartlett, A.T.M.; White, P.J.
Regulation of the enzymes of lysine biosynthesis in Bacillus sphaericus NCTC 9602 during vegetative growth
J. Gen. Microbiol.
132
3169-3177
1986
Lysinibacillus sphaericus
-
Chatterjee, M.; Chatterjee, S.P.; White, P.J.
The mechanism of threonine inhibition of growth and lysine production of Micrococcus luteus 236b
FEMS Microbiol. Lett.
12
163-166
1981
Micrococcus luteus
-
Holland, M.J.; Westhead, E.W.
Chemical reactivity at the catalytic sites of aspartic -semialdehyde dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase
Biochemistry
12
2276-2281
1973
Saccharomyces cerevisiae
Holland, M.J.; Westhead, E.W.
Adenosine 5-triphosphate induced cold inactivation of yeast aspartic -semialdehyde dehydrogenase
Biochemistry
12
2270-2275
1973
Saccharomyces cerevisiae
Hadfield, A.; Kryger, G.; Ouyang, J.; Petsko, G.A.; Ringe, D.; Viola, R.
Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis
J. Mol. Biol.
289
991-1002
1999
Escherichia coli (P0A9Q9), Escherichia coli
Kish, M.M.; Viola, R.E.
Oxyanion specificity of L-Aspartate-beta-semialdehyde dehydrogenase
Inorg. Chem.
38
818-820
1999
Escherichia coli
Zhang, W.W.; Jiang, W.H.; Zhao, G.P.; Yang, Y.L.; Chiao, J.S.
Expression in Escherichia coli, purification and kinetic analysis of the aspartokinase and aspartate semialdehyde dehydrogenase from the rifamycin SV-producing Amycolatopsis mediterranei U32
Appl. Microbiol. Biotechnol.
54
52-58
2000
Amycolatopsis mediterranei U32
Moore, R.A.; Bocik, W.E.; Viola, R.E.
Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms
Protein Expr. Purif.
25
189-194
2002
Haemophilus influenzae, Helicobacter pylori (O25801), Helicobacter pylori, Vibrio cholerae (P23247), Vibrio cholerae, Pseudomonas aeruginosa (Q51344), Pseudomonas aeruginosa
Paris, S.; Wessel, P.M.; Dumas, R.
Overproduction, purification, and characterization of recombinant aspartate semialdehyde dehydrogenase from Arabidopsis thaliana
Protein Expr. Purif.
24
99-104
2002
Arabidopsis thaliana (Q9FVC4), Arabidopsis thaliana
Blanco, J.; Moore, R.A.; Faehnle, C.R.; Coe, D.M.; Viola, R.E.
The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase
Acta Crystallogr. Sect. D
60
1388-1395
2004
Haemophilus influenzae
Blanco, J.; Moore, R.A.; Faehnle, C.R.; Viola, R.E.
Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase
Acta Crystallogr. Sect. D
60
1808-1815
2004
Haemophilus influenzae (P44801), Haemophilus influenzae
Faehnle, C.R.; Blanco, J.; Viola, R.E.
Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase
Acta Crystallogr. Sect. D
60
2320-2324
2004
Haemophilus influenzae (P44801)
Alvarez, E.; Ramon, F.; Magan, C.; Diez, E.
L-cystine inhibits aspartate-beta-semialdehyde dehydrogenase by covalently binding to the essential 135Cys of the enzyme
Biochim. Biophys. Acta
1696
23-29
2004
Escherichia coli
Shafiani, S.; Sharma, P.; Vohra, R.M.; Tewari, R.
Cloning and characterization of aspartate-beta-semialdehyde dehydrogenase from Mycobacterium tuberculosis H37 Rv
J. Appl. Microbiol.
98
832-838
2005
Mycobacterium tuberculosis (P9WNX5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNX5), Mycobacterium tuberculosis H37Rv
Nichols, C.E.; Dhaliwal, B.; Lockyer, M.; Hawkins, A.R.; Stammers, D.K.
High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate beta-semialdehyde dehydrogenase
J. Mol. Biol.
341
797-806
2004
Escherichia coli (P0A9Q9), Escherichia coli
Blanco, J.; Moore, R.A.; Viola, R.E.
Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase
Proc. Natl. Acad. Sci. USA
100
12613-12617
2003
no activity in Homo sapiens, Haemophilus influenzae (P44801), Haemophilus influenzae
Blanco, J.; Moore, R.A.; Kabaleeswaran, V.; Viola, R.E.
A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae
Protein Sci.
12
27-33
2003
Vibrio cholerae (Q9KQG2), Vibrio cholerae
Tunca, S.; Yilmaz, E.I.; Piret, J.; Liras, P.; Ozcengiz, G.
Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus
Res. Microbiol.
155
525-534
2004
Streptomyces clavuligerus (Q8KQ27), Streptomyces clavuligerus, Streptomyces clavuligerus NRRL 3585 (Q8KQ27)
Cahyanto, M.N.; Kawasaki, H.; Nagashio, M.; Fujiyama, K.; Seki, T.
Regulation of aspartokinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase and dihydrodipicolinate reductase in Lactobacillus plantarum
Microbiology
152
105-112
2006
Lactiplantibacillus plantarum, Lactiplantibacillus plantarum NCIMB 8826
Cox, R.J.; Gibson, J.S.; Hadfield, A.T.
Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase
ChemBiochem
6
2255-2260
2005
Bacteria, Escherichia coli (P0A9Q9)
Faehnle, C.R.; Le Coq, J.; Liu, X.; Viola, R.E.
Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria
J. Biol. Chem.
281
31031-31040
2006
Streptococcus pneumoniae
Faehnle, C.R.; Ohren, J.F.; Viola, R.E.
A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii
J. Mol. Biol.
353
1055-1068
2005
Methanocaldococcus jannaschii
Carroll, A.R.; Ngo, A.; Quinn, R.J.; Redburn, J.; Hooper, J.N.
Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp
J. Nat. Prod.
68
804-806
2005
Helicobacter pylori
Viola, R.E.; Liu, X.; Ohren, J.F.; Faehnle, C.R.
The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae
Acta Crystallogr. Sect. D
D64
321-330
2008
Vibrio cholerae serotype O1
Vyas, R.; Kumar, V.; Panjikar, S.; Karthikeyan, S.; Kishan, K.V.; Tewari, R.; Weiss, M.S.
Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
64
167-170
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WNX5), Mycobacterium tuberculosis H37Rv (P9WNX5)
Cahyanto, M.N.; Kawasaki, H.; Nagashio, M.; Fujiyama, K.; Seki, T.
Construction of Lactobacillus plantarum strain with enhanced L-lysine yield
J. Appl. Microbiol.
102
674-679
2007
Lactiplantibacillus plantarum, Lactiplantibacillus plantarum IAM 12477
Singh, A.; Kushwaha, H.R.; Sharma, P.
Molecular modelling and comparative structural account of aspartyl beta-semialdehyde dehydrogenase of Mycobacterium tuberculosis (H37Rv)
J. Mol. Model.
14
249-263
2008
Mycobacterium tuberculosis (P9WNX5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNX5)
Arachea, B.T.; Liu, X.; Pavlovsky, A.G.; Viola, R.E.
Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog
Acta Crystallogr. Sect. D
66
205-212
2010
Candida albicans (Q5ALM0)
Vyas, R.; Tewari, R.; Weiss, M.S.; Karthikeyan, S.
Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
68
671-679
2012
Mycobacterium tuberculosis (P9WNX5), Mycobacterium tuberculosis H37Rv (P9WNX5), Mycobacterium tuberculosis H37Rv
Luniwal, A.; Wang, L.; Pavlovsky, A.; Erhardt, P.W.; Viola, R.E.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
Bioorg. Med. Chem.
20
2950-2956
2012
Streptococcus pneumoniae, Vibrio cholerae (Q9KQG2), Vibrio cholerae
Viola, R.E.; Faehnle, C.R.; Blanco, J.; Moore, R.A.; Liu, X.; Arachea, B.T.; Pavlovsky, A.G.
The catalytic machinery of a key enzyme in amino acid biosynthesis
J. Amino Acids
2011
352538
2011
Candida albicans, Streptococcus pneumoniae, Escherichia coli, Methanocaldococcus jannaschii, Haemophilus influenzae (P44801), Vibrio cholerae (Q9KQG2)
Evitt, A.S.; Cox, R.J.
Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase
Mol. Biosyst.
7
1564-1575
2011
Salmonella enterica
Santander, J.; Xin, W.; Yang, Z.; Curtiss, R.
The aspartate-semialdehyde dehydrogenase of Edwardsiella ictaluri and its use as balanced-lethal system in fish vaccinology
PLoS ONE
5
e15944
2010
Edwardsiella ictaluri (C5BB06), Edwardsiella ictaluri, Edwardsiella ictaluri 93-146 (C5BB06)
Dahal, G.; Viola, R.E.
Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans
Acta Crystallogr. Sect. F
71
1365-1371
2015
Cryptococcus neoformans var. neoformans (Q5KPK7), Cryptococcus neoformans var. neoformans ATCC MYA-565 (Q5KPK7)
Dahal, G.P.; Viola, R.E.
Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus
Acta Crystallogr. Sect. F
73
36-44
2017
Aspergillus fumigatus (Q4WWR8), Aspergillus fumigatus, Aspergillus fumigatus ATCC MYA-4609 (Q4WWR8), no activity in Homo sapiens
Oogai, Y.; Yamaguchi, M.; Kawada-Matsuo, M.; Sumitomo, T.; Kawabata, S.; Komatsuzawa, H.
Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum
Appl. Environ. Microbiol.
82
6150-6157
2016
Staphylococcus aureus, Staphylococcus aureus MW2
Thangavelu, B.; Bhansali, P.; Viola, R.E.
Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors
Bioorg. Med. Chem.
23
6622-6631
2015
Streptococcus pneumoniae, Vibrio cholerae serotype O1
Xu, X.; Chen, J.; Wang, Q.; Duan, C.; Li, Y.; Wang, R.; Yang, S.
Mutagenesis of key residues in the binding center of L-aspartate-beta-semialdehyde dehydrogenase from Escherichia coli enhances utilization of the cofactor NAD(H)
ChemBioChem
17
56-64
2016
Escherichia coli (P0A9Q9), Escherichia coli
Meng, J.; Yang, Y.; Xiao, C.; Guan, Y.; Hao, X.; Deng, Q.; Lu, Z.
Identification and validation of aspartic acid semialdehyde dehydrogenase as a new anti-Mycobacterium tuberculosis target
Int. J. Mol. Sci.
16
23572-23586
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Subramani, P.; Mahendran, R.; Michael, R.
Molecular docking and dynamics simulation of Vibrio anguillarum aspartate semialdehyde dehydrogenase with natural product caulerpin
Lett. Drug Design Disc.
13
255-261
2016
Vibrio anguillarum
-
Mank, N.; Pote, S.; Majorek, K.; Arnette, A.; Klapper, V.; Hurlburt, B.; Chruszcz, M.
Structure of aspartate beta-semialdehyde dehydrogenase from Francisella tularensis
Acta Crystallogr. Sect. F
74
14-22
2018
Francisella tularensis subsp. tularensis (Q5NHM4), Francisella tularensis subsp. tularensis Schu 4 (Q5NHM4)
Dahal, G.P.; Viola, R.E.
Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase
Biochem. Biophys. Res. Commun.
503
2848-2854
2018
Blastomyces dermatitidis (C5GC63), Blastomyces dermatitidis, Blastomyces dermatitidis ER-3 (C5GC63), Blastomyces dermatitidis ATCC MYA-2586 (C5GC63)
Dahal, G.P.; Launder, D.; McKeone, K.M.M.; Hunter, J.P.; Conti, H.R.; Viola, R.E.
Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans
Drug Dev. Res.
81
736-744
2020
Candida albicans, Candida albicans CAF2-1
Khan, S.; Somvanshi, P.; Bhardwaj, T.; Mandal, R.K.; Dar, S.A.; Wahid, M.; Jawed, A.; Lohani, M.; Khan, M.; Areeshi, M.Y.; Haque, S.
Aspartate-beta-semialdeyhyde dehydrogenase as a potential therapeutic target of Mycobacterium tuberculosis H37Rv Evidence from in silico elementary mode analysis of biological network model
J. Cell. Biochem.
119
2832-2842
2018
Mycobacterium tuberculosis (P9WNX5), Mycobacterium tuberculosis H37Rv (P9WNX5), Mycobacterium tuberculosis ATCC 25618 (P9WNX5)
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