Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.2.1.11: aspartate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about aspartate-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.11

Reaction

L-aspartate 4-semialdehyde
+
phosphate
+
NADP+
=
L-4-aspartyl phosphate
+
NADPH
+
H+

Synonyms

AFUA_3G06830, ASA dehydrogenase, ASA DH, ASA-DH, ASADH, ASADHD, Asd, ASD enzyme, Asd1, Asd2, AsdA, aspartate beta-semialdehyde dehydrogenase, aspartate semialdehyde dehydrogenase, aspartate-beta-semialdehyde dehydrogenase, aspartate-beta-semialdeyhyde dehydrogenase, aspartate-semialdehyde dehydrogenase, aspartic acid semialdehyde dehydrogenase, aspartic beta-semialdehyde dehydrogenase, aspartic semialdehyde dehydrogenase, aspartyl beta-semialdehyde dehydrogenase, aspartyl semialdehyde dehydrogenase, BDCG_01946, CNA02450, dehydrogenase, aspartate semialdehyde, ecASADH, FtASADH, hiASADH, L-aspartate-beta-semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosphorylating), Rv3708c

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.11 aspartate-semialdehyde dehydrogenase

KI Value

KI Value on EC 1.2.1.11 - aspartate-semialdehyde dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.11 - 0.18
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
0.69 - 1.2
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
1.2 - 2.1
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
0.4 - 1.1
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
2.6 - 3.3
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
0.15 - 0.18
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
1.2
(S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid
0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C
3.9
(S)-2-amino-5-phosphono-pent-4-ynoic acid
0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C
0.062
1,4-Naphthoquinone
-
pH and temperature not specified in the publication
0.093
1-amino-2-naphthol-4-sulfonic acid
-
pH and temperature not specified in the publication
-
0.05
2'-phosphoribose AMP
-
-
0.00065
2,3-dichloro-1,4-naphthoquinone
-
pH and temperature not specified in the publication
0.0576
2,3-dichloro-5,6-dicyano-1,4-benzoquinone
-
pH and temperature not specified in the publication
0.0115
2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone
-
pH and temperature not specified in the publication
-
0.0061
2-bromo-1,4-naphthoquinone
-
pH and temperature not specified in the publication
-
0.0041
2-Chloro-1,4-naphthoquinone
-
pH and temperature not specified in the publication
0.04
3-Chloroacetylpyridine-adenine dinucleotide phosphate
-
competitive inhibitor with respect to NADP+
0.324 - 0.654
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
0.296 - 0.609
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
0.126
4-benzoquinone
pH 8.6, 25°C, recombinant enzyme
4
4-nitro-N,N-diethylbenzimidazolinone
0.086
4-nitro-N,N-dimethylbenzimidazolinone
4
4-nitro-N-ethylphthalimide
0.89 - 1.1
4-nitro-N-methylphthalimide
0.084
5-aminoisoquinoline
-
pH and temperature not specified in the publication
-
20
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
0.121
catechol
-
pH and temperature not specified in the publication
0.154
cyclohexyl iodide
-
pH and temperature not specified in the publication
-
20
dimethyl pyridine-2,5-dicarboxylate
10
homocysteine
-
-
20
methyl 5-nitropyridine-2-carboxylate
0.476 - 1.1
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.396 - 0.749
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.529 - 0.737
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.524 - 0.721
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.329 - 0.724
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.54 - 0.708
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.509 - 0.727
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.442 - 0.665
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.43 - 0.69
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.427 - 0.684
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.441 - 0.678
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.009 - 0.639
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
0.012 - 0.634
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
3.6
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.057 - 0.629
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.229 - 0.649
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.072 - 0.635
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.054 - 0.698
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.063 - 0.608
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.016 - 0.648
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.036 - 0.663
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.024 - 3.8
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.176 - 0.692
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.276 - 0.655
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
0.22 - 0.498
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
0.303 - 0.663
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
0.297 - 0.696
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
2.4
N-carboxyethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.246 - 0.528
N-carboxymethyl-3,4-dicarboxybenzylamine
0.296 - 0.675
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
0.045
naphthalene-2,3-dialdehyde
-
pH and temperature not specified in the publication
-
0.073
p-benzoquinone
-
pH and temperature not specified in the publication
0.065
p-hydroquinone
-
pH and temperature not specified in the publication
0.22
Periodate
-
-
140
perrhenate
-
-
17
phosphonate
-
-
0.063
phthalaldehyde
-
pH and temperature not specified in the publication
11
tellurate
-
-
0.066
tetrachloro-1,4-benzoquinone
-
pH and temperature not specified in the publication
26
tungstate
-
-
20
z-olefin
-
-
-
additional information
additional information
-
inhibition kinetics at 21°C and pH 7.5
-