1.2.1.10: acetaldehyde dehydrogenase (acetylating)

This is an abbreviated version!
For detailed information about acetaldehyde dehydrogenase (acetylating), go to the full flat file.

Reaction

Synonyms

4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase, ACDH, acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating], acetaldehyde-alcohol dehydrogenase, acetyl-CoA reductase, acylating acetaldehyde dehydrogenase, AdhE, ADHES77, aldehyde dehydrogenase, aldehyde dehydrogenase (acylating), aldehyde/alcohol dehydrogenase, ALDH, BAD, bi-functional alcohol/aldehyde dehydrogenase, bifunctional acetaldehyde-alcohol dehydrogenase, BphJ, CoA-acylating aldehyde dehydrogenase, CoA-dependent aldehyde dehydrogenase, coenzyme A linked aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, DmpF, DmpFG, MhpF, More, NAD+/CoA-dependent aldehyde dehydrogenase, nonphosphorylating acylating aldehyde dehydrogenase, PduP, Teth514_0627, Teth514_1942, Tsac_0416, TTHB247

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.10 acetaldehyde dehydrogenase (acetylating)

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Results	in table
8	Activating Compound
8247	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
69	Cofactor
3	Crystallization (Commentary)
3	Expression
21	General Information
7	General Stability
25	Inhibitors
39	kcat/KM [mM/s]
4	Ki Value [mM]
94	KM Value [mM]
13	Localization
3	Metals/Ions
33	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
256	Organism
1	Oxidation Stability
31	Pathway
36	PDB ID
17	pH Optimum
10	pH Range
2	pH Stability
1	pI Value
16	Protein Variants
19	Purification (Commentary)
8	Reaction
4	Reaction Type
55	Reference
3	Source Tissue
31	Specific Activity [micromol/min/mg]
10	Storage Stability
151	Substrates and Products (Substrate)
29	Subunits
65	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
4	Temperature Range [°C]
8	Temperature Stability [°C]
26	Turnover Number [1/s]

General Stability

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General Stability on EC 1.2.1.10 - acetaldehyde dehydrogenase (acetylating)

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

activity is highest in HEPES buffer and somewhat lower in phosphate buffer, activity in Tris buffer is about half the rate in HEPES buffer

Pseudomonas sp.

-

390175

dithioerythritol stabilizes

Clostridium kluyveri

-

390176

extremely unstable in absence of 2-mercaptoethanol

Escherichia coli

-

390171

labile during purification, stabilization by 2-hydroxyethyldisulfide

Escherichia coli

-

390164

no stabilization by detergents, acetone, ethanol, NAD+, glycerol, CoA, anaerobic conditions

Clostridium kluyveri

-

390176

sensitive to O2, can be protected against O2 inactivation by dithiothreitol

Clostridium beijerinckii

-

390174

with Tris acetate buffer at pH 7, less stable at higher buffer concentration between 10 and 150 mM

Clostridium beijerinckii

-

390174