1.18.1.6: adrenodoxin-NADP+ reductase
This is an abbreviated version!
For detailed information about adrenodoxin-NADP+ reductase, go to the full flat file.
Word Map on EC 1.18.1.6
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1.18.1.6
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dioxygenase
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carbazole
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1,9a-dioxygenase
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25-hydroxyvitamin
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cardo
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rieske
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p450scc
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cyp11a1
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rieske-type
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26-hydroxylation
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alpha-triol
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putidaredoxin
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beta-cholestane-3
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ring-hydroxylating
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meta-cleavage
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novosphingobium
- 1.18.1.6
- dioxygenase
- carbazole
-
1,9a-dioxygenase
-
25-hydroxyvitamin
- cardo
-
rieske
- p450scc
- cyp11a1
-
rieske-type
-
26-hydroxylation
-
alpha-triol
- putidaredoxin
-
beta-cholestane-3
-
ring-hydroxylating
-
meta-cleavage
- novosphingobium
Reaction
2 reduced adrenodoxin
+
Synonyms
AdR, adrenodoxin oxidoreductase, adrenodoxin reductase, ADX reductase, AdxR, FDXR, ferredoxin reductase, FLP, FprA, NADPH adrenodoxin reductase, NADPH-adrenodoxin reductase, NADPH-dependent adrenodoxin reductase, NADPH:adrenal ferredoxin adrenodoxin reductase, NADPH:adrenal ferredoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase mitochondrial, NADPH:adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, TPNH-cytochrome P-450 reductase
ECTree
1.18.1.6 adrenodoxin-NADP+ reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.18.1.6 - adrenodoxin-NADP+ reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
diaphorase activity
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADPH
reduced 2,6-dichlorophenolindophenol + NADP+ + H+
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-
-
r
oxidized adrenodoxin + NADH + H+
reduced adrenodoxin + NAD+
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the enzyme has low affinity for NADH
-
-
?
reduced ferredoxin + NAD(P)+
oxidized ferredoxin + NAD(P)H
-
-
-
r
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
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the enzyme also has NADPH-ferricyanide activity
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-
?
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
diaphorase activity
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
first enzyme in mitochondrial P-450-linked monooxygenase system catalyzing several steps in the biosynthesis of steroid hormones, bile acids or vitamin D3 in various tissues
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-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
first enzyme in mitochondrial P-450-linked monooxygenase system catalyzing several steps in the biosynthesis of steroid hormones, bile acids or vitamin D3 in various tissues
-
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
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285412, 718572, 718822, 718957, 719028, 719386, 719389, 719445, 719482, 719751, 719768, 719775, 719777
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-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
-
best substrate combination
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-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
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tightly and loosely bound enzyme forms show similar activities
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-
?
reduced adrenodoxin + NADP+ + H+
oxidized adrenodoxin + NADPH
-
-
-
-
?
additional information
?
-
-
adrenodoxin stimulates the oxidation of NADPH by 1,4-benzoquinone, catalyzed by NADPH:adrenodoxin reductase. It prevents the enzyme inhibition by NADPH and forms an additional pathway of benzoquinone reduction presumably via reduced adrenodoxin. Adrenodoxin decreases the affinity of the enzyme for NADPH by a limiting factor of 3 and NADP+ decreases the enzyme affinity for adrenodoxin
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-
?
additional information
?
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anaerobic reduction of AdR with NADPH or the photoreduction of AdR in the presence of NADP+ and EDTA produces a multicomponent equilibrium which is dependent upon the concentration of NADPH and the temperature
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-
?
additional information
?
-
-
modified adrenodoxin (at His-10, His-66, and His-62 with diethyl dicarbonate) exhibits reduced affinity for adrenodoxin reductase
-
-
?
additional information
?
-
-
NADP+ is also oxidized to 3-carboxamide-4-pyridone adenine dinucleotide phosphate by adrenodoxin reductase in the presence of air oxygen
-
-
?
additional information
?
-
the enzyme contains a second, kinetically distinct and inhibitory pyridine nucleotide-binding site
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-
?
additional information
?
-
-
the enzyme contains a second, kinetically distinct and inhibitory pyridine nucleotide-binding site
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-
?
