1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)
This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.
Word Map on EC 1.17.4.2
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1.17.4.2
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hydroxyurea
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deoxyribonucleotides
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dntp
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rr
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herpes
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tyrosyl
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simplex
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gemcitabine
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leukemia
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reductases
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thymidine
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thioredoxins
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deoxycytidine
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deoxynucleotides
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cdp
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s-phase
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thymidylate
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thiosemicarbazone
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glutaredoxins
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checkpoint
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nsclc
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cytidine
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diferric
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deoxyadenosine
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diiron
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fork
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deoxyguanosine
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5'-diphosphate
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nonidentical
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gallium
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antiferromagnetically
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hyperfine
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proton-coupled
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dinuclear
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oncolytic
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cross-complementation
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acyclovir
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cladribine
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chk1
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thiyl
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aphidicolin
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cross-complementing
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endor
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fludarabine
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b12-dependent
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gemcitabine-based
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deoxythymidine
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analysis
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gemcitabine-induced
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high-valent
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peroxo
- 1.17.4.2
- hydroxyurea
- deoxyribonucleotides
- dntp
- rr
- herpes
-
tyrosyl
- simplex
- gemcitabine
- leukemia
- reductases
- thymidine
- thioredoxins
- deoxycytidine
-
deoxynucleotides
- cdp
-
s-phase
- thymidylate
- thiosemicarbazone
- glutaredoxins
-
checkpoint
-
nsclc
- cytidine
-
diferric
- deoxyadenosine
-
diiron
-
fork
- deoxyguanosine
- 5'-diphosphate
-
nonidentical
- gallium
-
antiferromagnetically
-
hyperfine
-
proton-coupled
-
dinuclear
-
oncolytic
-
cross-complementation
- acyclovir
- cladribine
- chk1
-
thiyl
- aphidicolin
-
cross-complementing
-
endor
- fludarabine
-
b12-dependent
-
gemcitabine-based
- deoxythymidine
- analysis
-
gemcitabine-induced
-
high-valent
-
peroxo
Reaction
Synonyms
2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR
ECTree
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)Advanced search results
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results (Engineering
Engineering on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C408A
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only wild-type enzyme catalyzes epimerization of the (5'S)-[5'-2H1]- and (5'R)-[5'-2H1]-isotopomers of adenosylcobalamin, no activity of mutant enzyme
C408S
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only wild-type enzyme catalyzes epimerization of the (5'S)-[5'-2H1]- and (5'R)-[5'-2H1]-isotopomers of adenosylcobalamin, no activity of mutant enzyme
additional information
additional information
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mutants in subunit R2 isoform tso2 show reduced deoxyribonucleotide triphosphate levels and developmental defects including callus-like floral organs and fasciated shoot apical stems. R2 isoforms tso2 single and tso2/rnr2a double mutants are more sensitive to UV-C light and double mutant seedlings exhibit increased DNA damage, massive programmed cell death, and release of transcriptional gene silencing
additional information
mutants in subunit R2 isoform tso2 show reduced deoxyribonucleotide triphosphate levels and developmental defects including callus-like floral organs and fasciated shoot apical stems. R2 isoforms tso2 single and tso2/rnr2a double mutants are more sensitive to UV-C light and double mutant seedlings exhibit increased DNA damage, massive programmed cell death, and release of transcriptional gene silencing
additional information
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mutation cls8, i.e. crinkled leaves8, is a mutant of the large subunit R1 of ribonucleotide reductase. the mutation leads to abnormal leaf and flower morphology, reduced root growth and bleache leaf sections. Levels of dTTP and dATP are significantly reduced
additional information
construction of two T-DNA insertion mutants of the RNR2Tso2, inserted within the coding sequence of the second exon of RNR2Tso2. No plants homozygous for the T-DNA allele are detectable for either allele
additional information
construction of two T-DNA insertion mutants of the RNR2Tso2, inserted within the coding sequence of the second exon of RNR2Tso2. No plants homozygous for the T-DNA allele are detectable for either allele
additional information
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construction of two T-DNA insertion mutants of the RNR2Tso2, inserted within the coding sequence of the second exon of RNR2Tso2. No plants homozygous for the T-DNA allele are detectable for either allele
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additional information
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fnr and arcA mutant strains are constructed by introducing the indicated mutation into strain IG40 by P1 transduction followed by selection for the appropriate drug resistance
additional information
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in p53null cells, siRNA-mediated knockdown of about 80% of R2 subunits has no effect on proliferative growth but results in enhanced accumulation of gamma-H2Ax and delayed recovery from DNA lesions inflicted by exposure to cisplatin and Triapine. Level of R1 subunits is limiting since depletion of the R1 subunit directly activates the S phase checkpoint due to replication stress
additional information
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isolation of a p53R2 mutant from skin fibroblasts, quiescent p53R2 mutant cells contain more isozyme R2, incorporate more BrdU into cell nuclei, and synthesize more DNA from dTMP than matched controls
additional information
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generation of RNR transgenic mice expressing one or more subunits of RNR, phenotypes, overview
additional information
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cell lacking thioredoxins exhibit an elongated S phase and accumulate subunit R1 in its oxidized form. Cells also contain significantly decreased deoxyribonucleotide levels during the S phase. Overexpressing subunit R1 in these cells increases both the amount of R1 reduced form and the concentrations of deoxyribonucleotides and accelerates DNA replication
