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1.16.1.8: [methionine synthase] reductase

This is an abbreviated version!
For detailed information about [methionine synthase] reductase, go to the full flat file.

Word Map on EC 1.16.1.8

Reaction

2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine +

NADP+
= 2 [methionine synthase]-cob(II)alamin +
NADPH
+
H+
+ 2 S-adenosyl-L-methionine

Synonyms

EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase

ECTree

     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.8 [methionine synthase] reductase

Systematic Name

Systematic Name on EC 1.16.1.8 - [methionine synthase] reductase

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SYSTEMATIC NAME
IUBMB Comments
[methionine synthase]-methylcob(III)alamin,S-adenosyl-L-homocysteine:NADP+ oxidoreductase
In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.