1.16.1.8: [methionine synthase] reductase
This is an abbreviated version!
For detailed information about [methionine synthase] reductase, go to the full flat file.
Word Map on EC 1.16.1.8
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1.16.1.8
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mthfr
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folate
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methylenetetrahydrofolate
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case-control
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gg
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hyperhomocysteinemia
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one-carbon
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cystathionine
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tetrahydrofolate
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folic
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remethylation
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thymidylate
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beta-synthase
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transcobalamin
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methylmalonic
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megaloblastic
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folate-related
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spina
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bifida
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cobiialamin
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methyltetrahydrofolate
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cobalamin-dependent
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homocystinuria
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gcpii
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diagnostics
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t-hcys
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medicine
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folate-metabolizing
- 1.16.1.8
- mthfr
- folate
- methylenetetrahydrofolate
-
case-control
- gg
- hyperhomocysteinemia
-
one-carbon
- cystathionine
- tetrahydrofolate
-
folic
-
remethylation
- thymidylate
- beta-synthase
-
transcobalamin
-
methylmalonic
-
megaloblastic
-
folate-related
-
spina
- bifida
-
cobiialamin
- methyltetrahydrofolate
-
cobalamin-dependent
- homocystinuria
- gcpii
- diagnostics
-
t-hcys
- medicine
-
folate-metabolizing
Reaction
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + = 2 [methionine synthase]-cob(II)alamin + + + 2 S-adenosyl-L-methionine
Synonyms
EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase
ECTree
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Reaction
Reaction on EC 1.16.1.8 - [methionine synthase] reductase
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2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
under anaerobic growth conditions, oxidized ferredoxin (flavodoxin):NADP+ oxidoreductase accepts a hydride from NADPH and transfers the electron to flavodoxin, generating primarily flavodoxin semiquinone. Under anaerobic conditions the decarboxylation of pyruvate is coupled to reduction of flavodoxin, forming the flavodoxin hydroquinone. These reduced forms of flavodoxin bind to inactive cob(II)alamin enzyme, causing a conformational change that is coupled with dissociation of His759 and protonation of the His759-Asp757-Ser810 triad. Although NADPH oxidation ultimately produces 2 equivalent of flavodoxin semiquinone, only one electron is transferred to methionine synthase during reductive methylation
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2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
mechanism for the NADPH-catalyzed reduction of diflavin oxidoreductases, overview
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
hydride transfer and interflavin electron transfer are two catalytic steps represented by two distinct kinetic phases leading to transient formation of the FAD hydroquinone