1.16.1.6: cyanocobalamin reductase

This is an abbreviated version!
For detailed information about cyanocobalamin reductase, go to the full flat file.

Reaction

2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide +

Synonyms

cyanobalamin reductase (NADPH, cyanide-eliminating), cyanocobalamin reductase, cyanocobalamin reductase (NADPH, CN-eliminating), EC 1.6.99.12, NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating)

ECTree

     1 Oxidoreductases

         1.16 Oxidizing metal ions

             1.16.1 With NAD⁺ or NADP⁺ as acceptor

                1.16.1.6 cyanocobalamin reductase

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Results	in table
772	AA Sequence
1	CAS Registry Number
3	Cofactor
1	Localization
1	Natural Substrates/ Products (Substrates)
1	Organism
3	Pathway
1	pH Stability
1	Reaction
4	Reaction Type
1	Reference
1	Specific Activity [micromol/min/mg]
1	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.16.1.6 - cyanocobalamin reductase

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SYSTEMATIC NAME

IUBMB Comments

cob(II)alamin, hydrogen cyanide:NADP+ oxidoreductase

The mammalian enzyme, which is cytosolic, can bind internalized cyanocobalamin and process it to cob(II)alamin by removing the upper axial ligand. The product remains bound to the protein, which, together with its interacting partner MMADHC, transfers it directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. In addition to its decyanase function, the mammalian enzyme also catalyses an entirely different chemical reaction with alkylcobalamins, using the thiolate of glutathione for nucleophilic displacement, generating cob(I)alamin and the corresponding glutathione thioether (cf. EC 2.5.1.151, alkylcobalamin dealkylase).