1.16.1.1: mercury(II) reductase
This is an abbreviated version!
For detailed information about mercury(II) reductase, go to the full flat file.
Word Map on EC 1.16.1.1
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1.16.1.1
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organomercurial
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mercury-resistant
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hgcl2
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methylmercury
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lipoamide
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phytoremediation
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mercury-contaminated
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ferrooxidans
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hg-resistant
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geothermal
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metal-resistant
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phenylmercury
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mercury-polluted
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environmental protection
- 1.16.1.1
-
organomercurial
-
mercury-resistant
- hgcl2
- methylmercury
- lipoamide
-
phytoremediation
-
mercury-contaminated
- ferrooxidans
-
hg-resistant
-
geothermal
-
metal-resistant
- phenylmercury
-
mercury-polluted
- environmental protection
Reaction
Synonyms
bacterial mercuric reductase, Mer A, MerA, MerA protein, mercurate(II) reductase, mercuric (II) reductase, mercuric ion reductase, mercuric reductase, mercury reductase, Msed_1241, MseMerA, reduced NADP:mercuric ion oxidoreductase, reductase, mercurate(II), Rm CH34, Tn501 MerA, Tn501 mercuric ion reductase
ECTree
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Cofactor
Cofactor on EC 1.16.1.1 - mercury(II) reductase
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FAD
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a flavoprotein, spectral analysis of the binding structure and environment, overview
FAD
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flavoprotein. The large flexibility of the FAD structure and environment in MerA is in agreement with proposed mechanisms involving C4a(flavin) adducts
NADPH
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NADPH
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in the presence of an excess of NADPH, the final product of the reaction is probably an NADPH complex of two-electron-reduced enzyme, but below pH 6 the final spectrum becomes less intense suggesting a partial formation of four-electron-reduced enzyme
NADPH
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in presence of 1 mM cysteine only one equivalent of NADPH per FAD is required for full activation
NADPH
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the first two steps of the reaction involve 1 mol NADPH per mol FAD, the third requires a second equivalent of NADPH
the enzymes contains FAD, utilizes NADPH as an electron donor, and requires an excess of exogenous thiols for activity
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additional information
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each monomer contains a FAD and a redoxactive disulfide group close to the FAD isoalloxazine ring. MerA has an additional Cys/Cys redox site in the C-terminal part of its sequence
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