1.14.99.22: ecdysone 20-monooxygenase
This is an abbreviated version!
For detailed information about ecdysone 20-monooxygenase, go to the full flat file.
Word Map on EC 1.14.99.22
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1.14.99.22
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20-hydroxyecdysone
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ecdysteroids
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instar
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molt
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midguts
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manduca
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sexta
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wandering
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malpighian
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halloween
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hornworm
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ecdysteroidogenesis
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shade
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prothoracic
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moulting
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migratoria
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nondiapause
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neverland
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cyp18a1
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larval-pupal
- 1.14.99.22
- 20-hydroxyecdysone
- ecdysteroids
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instar
-
molt
- midguts
- manduca
- sexta
-
wandering
-
malpighian
-
halloween
- hornworm
-
ecdysteroidogenesis
-
shade
-
prothoracic
-
moulting
- migratoria
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nondiapause
- neverland
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cyp18a1
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larval-pupal
Reaction
Synonyms
alpha-ecdysone C-20 hydroxylase, BmE20OHase, Cyp314A1, E-20-M, E20-M, E20M, E20MO, E20OHase, ecdysone 20-hydroxylase, ecdysone 20-monooxygenase, shade, shd
ECTree
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Substrates Products
Substrates Products on EC 1.14.99.22 - ecdysone 20-monooxygenase
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REACTION DIAGRAM
ecdysone + reduced acceptor + O2
20-hydroxyecdysone + acceptor + H2O
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alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one, the 5alpha-epimer of ecdysone, 2beta-acetoxyecdysone, 3-hydroxyecdysone, 3-dehydro-ecdysone or ecdysterone are not hydroxylated
beta-ecdysone, ecdysterone
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alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
Parasarcophaga argyrostoma
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
alpha-ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
20-hydroxyecdysone + A + H2O
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the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone
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ecdysone + AH2 + O2
20-hydroxyecdysone + A + H2O
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the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone
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ecdysone + AH2 + O2
20-hydroxyecdysone + A + H2O
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the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone
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?
ecdysone + NADPH + H+ + O2
20-hydroxyecdysone + NADP+ + H2O
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ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
-
?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
-
?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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alpha-ecdysone, a secretory product of prothoracic glands
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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last step in biosynthesis of insect molting hormone
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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last step in biosynthesis of insect molting hormone
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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midgut microsomes show higher specific activity with 2fold higher Vmax, while total activity is 8-10fold higher in mitochondria
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
Parasarcophaga argyrostoma
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?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
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serves as precursor of ecdysterone, the active moulting hormone in larval insects
-
?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
-
serves as precursor of ecdysterone, the active moulting hormone in larval insects
-
?
ecdysone + NADPH + O2
20-hydroxyecdysone + NADP+ + H2O
-
serves as precursor of ecdysterone, the active moulting hormone in larval insects
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?
?
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recombinant GST-fusion protein, expressed in E. coli, is also able to transfer electrons from NADPH to a microsomal steroid hydroxylase p-450 and support steroidogenesis
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additional information
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E20-M preferentially uses NADPH in catalyzing ecdysone conversion to the physiologically active molting hormone, 20-hydroxyecdysone
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