1.14.99.1: prostaglandin-endoperoxide synthase
This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.
Word Map on EC 1.14.99.1
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1.14.99.1
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arachidonic
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indomethacin
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necrosis
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nsaid
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tnf
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lipopolysaccharide
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endothelial
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nonsteroidal
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celecoxib
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artery
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thromboxane
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aspirin
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lps
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lipoxygenase
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pain
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cardiovascular
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lps-induced
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platelet
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prostanoids
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agonist
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gastrointestinal
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mapks
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phospholipase
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gastric
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carcinogenesis
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eicosanoids
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leukotriene
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ulcer
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arthritis
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analgesic
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prostacyclin
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nf-kappab
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lps-stimulated
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colorectal
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angiogenesis
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edema
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tnf-alpha
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ibuprofen
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vasodilator
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il-1beta
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osteoarthritis
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nonselective
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factor-alpha
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chemopreventive
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lipopolysaccharide-induced
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factor-kappa
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endothelium-dependent
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vasoconstriction
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l-name
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endothelium-derived
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medicine
- 1.14.99.1
-
arachidonic
- indomethacin
- necrosis
-
nsaid
- tnf
- lipopolysaccharide
- endothelial
-
nonsteroidal
- celecoxib
- artery
-
thromboxane
- aspirin
- lps
- lipoxygenase
- pain
- cardiovascular
-
lps-induced
- platelet
-
prostanoids
- agonist
- gastrointestinal
- mapks
- phospholipase
- gastric
- carcinogenesis
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eicosanoids
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leukotriene
- ulcer
- arthritis
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analgesic
- prostacyclin
- nf-kappab
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lps-stimulated
- colorectal
- angiogenesis
- edema
- tnf-alpha
- ibuprofen
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vasodilator
- il-1beta
- osteoarthritis
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nonselective
- factor-alpha
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chemopreventive
-
lipopolysaccharide-induced
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factor-kappa
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endothelium-dependent
-
vasoconstriction
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l-name
-
endothelium-derived
- medicine
Reaction
Synonyms
(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2
ECTree
1.14.99.1 prostaglandin-endoperoxide synthaseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 1.14.99.1 - prostaglandin-endoperoxide synthase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
ellagic acid
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at high concentration and in presence of cofactors inhibition, at low concentrations stimulation
glutathione
promotes prostaglandin H synthase-dependent formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha
peroxynitrite
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peroxidase activity, MS-analysis reveals that tyrosine 385 is a target for nitration by ONOO- only when heme is present
Tannic acid
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at high concentration and in presence of cofactors inhibition, at low concentrations stimulation
additional information
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USF proteins are involved in the trans-activation of the PGH-2 promoter in granulosa cells
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additional information
the enzyme is induced by arachidonic acid up to 7.5-fold within 6 h, it is also induced by protein kinase C activators 4beta-PMA and PGF2alpha, all activation effects are blocked by PKC inhibitors, regulation, overview, protein kinase C induces PTGS2 independently of PPARs, i.e. peroxisome-proliferator-activated receptors
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additional information
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the enzyme is induced by arachidonic acid up to 7.5-fold within 6 h, it is also induced by protein kinase C activators 4beta-PMA and PGF2alpha, all activation effects are blocked by PKC inhibitors, regulation, overview, protein kinase C induces PTGS2 independently of PPARs, i.e. peroxisome-proliferator-activated receptors
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additional information
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cyclooxygenase catalysis by prostaglandin H synthase-1 and -2 requires activation of the normally latent enzyme by peroxide-dependent generation of a free radical at Tyr385 (PGHS-1 numbering) in the cyclooxygenase active site. The Tyr385 radical has also been linked to self-inactivation processes that impose an ultimate limit on cyclooxygenase catalysis
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additional information
hypoxia and glucose-free medium treatment synergistically increase PGHS-2 mRNA approximately 8fold
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additional information
oxygen and glucose depivation induce PGHS-2 gene expression synergistically in neurons
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additional information
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aqueous extracts of Chromoleana odorata, commonly used in traditional medicine as antiinflammatory drug against pains or as cataplasm to stop hemorrhage in Ivory Coast, the essential oil extracted from the fresh leaves activates the cyclooxygenase activity of the PGHS, overview
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additional information
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stimulation of enzyme in crude extract by some amines
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