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1.14.19.49: tetracycline 7-halogenase

This is an abbreviated version!
For detailed information about tetracycline 7-halogenase, go to the full flat file.

Reaction

tetracycline
+
FADH2
+
chloride
+
O2
+
H+
=
7-chlorotetracycline
+
FAD
+ 2 H2O

Synonyms

ctcP, Cts4

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.49 tetracycline 7-halogenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.19.49 - tetracycline 7-halogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(4S)-tetracycline + FADH2 + chloride + O2 + H+
7-chloro-(4S)-tetracycline + FAD + 2 H2O
show the reaction diagram