1.14.18.2: CMP-N-acetylneuraminate monooxygenase
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For detailed information about CMP-N-acetylneuraminate monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.2
Reaction
Synonyms
CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah
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Disease on EC 1.14.18.2 - CMP-N-acetylneuraminate monooxygenase
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DISEASE 
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Atherosclerosis
Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms.
Brain Neoplasms
Ganglioside biosynthetic gene expression in experimental mouse brain tumors.
cmp-n-acetylneuraminate monooxygenase deficiency
Pancreatic {beta}-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency.
Diabetes Mellitus, Type 2
MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.
Endotoxemia
Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State.
Glucose Intolerance
MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.
Hearing Loss
Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway.
Hearing Loss
Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss.
Hyperglycemia
MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.
Infections
Intestine specific regulation of pig cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase gene for N-glycolylneuraminic acid biosynthesis.
Lymphoma
CMP-N-acetylneuraminic acid hydroxylase activity determines the wheat germ agglutinin-binding phenotype in two mutants of the lymphoma cell line MDAY-D2.
Melanoma
Characterization of ganglioside expression in human melanoma cells: immunological and biochemical analysis.
Neoplasms
CMP-N-acetylneuraminic acid hydroxylase activity determines the wheat germ agglutinin-binding phenotype in two mutants of the lymphoma cell line MDAY-D2.
Severe Acute Respiratory Syndrome
High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2.
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