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1.14.18.1: tyrosinase

This is an abbreviated version!
For detailed information about tyrosinase, go to the full flat file.

Word Map on EC 1.14.18.1

Reaction

2 L-dopa +

O2
= 2 dopaquinone + 2 H2O

Synonyms

AbPPO1, AbPPO4, AbTYR, aurone synthase, catalase-phenol oxidase, catechol oxidase, catecholase, CATPO, chlorogenic acid oxidase, chlorogenic oxidase, cresolase, cresolase/monophenolase, CsPPO, CZA14Tyr, deoxy-tyrosinase, dihydroxy-L-phenylalanine:oxygen oxidoreductase, Diphenol oxidase, diphenolase, dopa oxidase, EC 1.10.3.1, EC 1.14.17.2, Hc-derived phenoloxidase, Hc-phenoloxidase, HcPO, HdPO, hemocyanin-derived phenoloxidase, jrPPO1, jrTYR, L-DOPA monophenolase, L-DOPA oxidase, L-DOPA:oxygen oxidoreductase, L-tyrosine hydroxylase, MdPPO1, melC2, MelC2 tyrosinase, met-tyrosinase, monophenol dihydroxyphenylalanine:oxygen oxidoreductase, monophenol monooxidase, monophenol monooxygenase, monophenol monoxygenase, monophenol oxidase, monophenol oxygen oxidoreductase, monophenol, 3,4-dihydroxy L-phenylalanine (L-DOPA):oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine:oxygen oxidoreductase, monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, monophenol, L-Dopa: oxidoreductase, monophenol, L-DOPA: oxygen oxidoreductase, monophenol, o-diphenol: oxygen oxidoreductase, monophenol, o-diphenol:O2 oxidoreductase, monophenol, o-diphenol:oxygen oxido-reductase, monophenol, o-diphenol:oxygen oxidoreductase, monophenol, polyphenol oxidase, monophenol: dioxygen oxidoreductases, hydroxylating, monophenolase, monphenol mono-oxygenase, More, mTyr, murine tyrosinase, mushroom tyrosinase, mushroom tyrosine, N-acetyl-6-hydroxytryptophan oxidase, o-diphenol oxidase, o-diphenol oxidoreductase, o-diphenol oxygen oxidoreductase, o-diphenol: O2 oxidoreductase, o-diphenol: oxidoreductase, o-diphenol:O2 oxidoreductase, o-diphenol:oxygen oxidoreductase, o-diphenolase, OCA1, Orf13, oxygen oxidoreductase, phenol oxidase, phenol oxidases, phenolase, phenoloxidase, PO, polyaromatic oxidase, polyphenol oxidase, polyphenol oxidase 3, polyphenol oxidase 4, polyphenol oxidase B, polyphenolase, polyphenoloxidase, PotPPO, PPO, PPO 3, PPO B, PPO1, PPO2, PPO3, pro-PO III, prophenoloxidase III, pyrocatechol oxidase, SPRTyr, ST94, ST94t, tryosinase, tryrosinase, TY, tyr, TYR1, TYR2, tyrA, TyrBm, tyrosinase, tyrosinase 2, tyrosinase 4, tyrosinase diphenolase, tyrosine-dopa oxidase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.1 tyrosinase

KM Value

KM Value on EC 1.14.18.1 - tyrosinase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.1 - 6.6
(+)-catechin
0.65
(-)-epicatechin
-
-
0.102
2,4,5-trihydroxyphenethylamine
-
-
0.37
2-caffeoylisocitric acid
-
apparent value
0.82
2-caffeoylisocitric acid 6-methyl ester
-
apparent value
2.7
2-Methylresorcinol
-
pH 7.0, 25°C
0.094
3,4,5-trihydroxyphenethylamine
-
-
0.305
3,4,6-trihydroxyphenylalanine
-
-
0.8
3,4-dihydroxyhydrocinnamic acid
-
at pH 7.0 and 22°C
0.047
3,4-Dihydroxyphenethylamine
-
-
1.89 - 5.1
3,4-dihydroxyphenyl propionic acid
1.3 - 19
3,4-dihydroxyphenylacetic acid
1.96
3,4-dihydroxyphenylalanine
-
-
0.046
3,4-dihydroxyphenylalanine methyl ester
-
-
0.02
3,4-dihydroxyphenylethanol
-
-
0.23
3,4-dihydroxyphenylglycol
-
-
0.24 - 0.7
3,4-Dihydroxyphenylpropionic acid
0.145
3,4-dihydroxyphenylserine
-
-
1240
3-(3,4-dihydroxyphenyl) propionic acid
-
0.194
3-(3,4-Dihydroxyphenyl)-2-methylalanine
-
-
1.25
3-(3,5-dihydroxyphenyl)-1-propanoic acid
recombinant enzyme, pH 7.2, 37°C
2.89
3-(p-hydroxyphenyl)propionic acid
-
-
11
3-chlorophenol
-
in 100 mM phosphate buffer, pH 6.8, at 25°C
6.9
3-Fluorophenol
-
-
0.78
3-hydroxyanthranilic acid
-
-
10.1
3-Hydroxybenzyl alcohol
-
-
0.2
3-hydroxyphloridzin
-
-
5.4
3-methoxyphenol
-
-
20
3-methylcatechol
-
-
0.71
3-[2-(3,4-dihydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-ethoxycarbonylphenyl)triazene
-
in phosphate buffer (pH 7.4), at 37°C
0.31
3-[2-(4-hydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-cyanophenyl)triazene
-
in phosphate buffer (pH 7.4), at 37°C
1.98
4-Bromophenol
-
pH and temperature not specified in the publication
0.6
4-Chlorocatechol
-
-
0.35 - 1.87
4-Chlorophenol
0.17
4-ethoxyphenol
0.17
4-Ethylcatechol
-
-
0.117
4-ethylresorcinol
-
pH 7.0, 25°C
0.41 - 2.9
4-Fluorophenol
0.08
4-hydroxyanisole
1.14 - 6.37
4-hydroxybenzaldehyde
6.33
4-hydroxybenzoic acid
-
-
1.1 - 14.77
4-Hydroxybenzyl alcohol
0.44 - 0.48
4-hydroxyphenyl propionic acid
0.18 - 1.91
4-hydroxyphenyl acetic acid
0.44
4-hydroxyphenyl propionic acid
-
-
0.22 - 6.7
4-hydroxyphenylpropionic acid
2.02
4-iodophenol
-
pH and temperature not specified in the publication
0.08
4-methoxyphenol
4 - 21
4-methyl catechol
2.62
4-methylbenzene-1,2-diol
-
apparent value
0.1 - 2000
4-methylcatechol
0.38
4-Methylphenol
-
pH and temperature not specified in the publication
0.203
4-methylresorcinol
-
pH 7.0, 25°C
0.1
4-nitrocatechol
-
-
136
4-t-butylcatechol
-
119
4-t-butylphenol
-
0.263 - 2.8
4-tert-butylcatechol
0.016 - 0.45
4-tert-butylphenol
2
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
-
-
1.45
Adrenaline bitartrate
-
-
6.5
alpha-arbutin
-
pH 7.0, 25°C
1.12
alpha-methyl-DL-tyrosine
-
-
2.5
alpha-Methyl-dopa
-
-
3.07
alpha-methyl-L-tyrosine
-
-
0.133
ascorbic acid
-
electron donor ascorbic acid
3
beta-arbutin
0.037 - 174.5
caffeic acid
0.479 - 4.7
catechin
0.014 - 2250
catechol
0.49 - 129.5
chlorogenic acid
4.6
Coke gallic acid
-
pH 6.8, 30°C
-
4.28
D-ascorbic acid
-
-
3 - 5
D-catechin
0.026 - 28.7
D-Dopa
3.22 - 6.67
D-epicatechin
0.24 - 1.86
D-Tyr
1.2 - 15
D-tyrosine
0.033
deoxyarbutin
pH and temperature not specified in the publication
2.86
diphenol
Helix vulgaris
-
the Km value is very close to those of Helix pomatia and Sepia officinalis Hcs, but several times higher compared to those of Rapana and Octopus Hcs
1.2
DL-2-methyltyrosine
-
-
0.022 - 9.56
DL-dopa
3.03 - 5.26
DL-epicatechin
1.64
DL-tyrosine
-
-
0.25 - 8.63
Dopa
1
dopa methyl ester
-
-
0.11 - 122
dopamine
0.1 - 0.12
ellagic acid
0.314 - 5.7
epicatechin
2
epicatechin gallate
-
-
2.2 - 28
epigallocatechin
2 - 32
epigallocatechin gallate
1.13
epinephrine
-
-
0.63 - 3.24
esculetin
0.071
gallate
-
pH 8.5, 15°C
0.18 - 21.2
gallic acid
7.8
gamma-L-glutaminyl-3,4-dihydroxybenzene
-
-
0.3
gamma-L-Glutaminyl-4-hydroxybenzene
-
-
0.11 - 3.1
Gly-Gly-L-Tyr
0.18 - 3.9
Gly-L-Tyr-Gly
38
guaiacol
pH 5.6, 37°C
25.6
guaiacolum
-
pH 6.8, 30°C
1
H2O2
-
at pH 8.0 and 37°C
0.67 - 27.4
Hydrocaffeic acid
0.92
hydroquinone
-
pH 7.0, 25°C
2 - 14
Hydroquinone monomethylether
-
range of estimated values for crude or purified extracts
0.4
Hydroxyhydroquinone
-
pH and temperature not specified in the publication
13.7
L-adrenaline
-
-
1.2
L-alpha-methyl tyrosine
-
-
2.5 - 6.8
L-alpha-methyldopa
2.79
L-ascorbic acid
-
-
0.016 - 1930
L-Dopa
1.9 - 4.2
L-dopa methyl ester
3.85 - 11.1
L-epicatechin
7.1 - 230
L-isoproterenol
0.21 - 1
L-Tyr
0.21 - 6
L-Tyr-Gly-Gly
0.014 - 145
L-tyrosine
0.38 - 1.66
L-tyrosine methyl ester
0.28 - 0.82
methyl 3-hydroxy-L-tyrosinate
0.12
methyl gallate
-
-
0.13
methylgallate
-
pH 8.5, 15°C
0.014
N-acetyl-3,4-dihydroxyphenethylamine
-
-
0.48
N-acetyldopamine
-
-
0.1
N-beta-alanyldopamine
-
-
8
N-Formyl-L-tyrosine
-
-
0.024
N-methyl-3,4-dihydroxyphenethylamine
-
-
0.61
norepinephrine
-
-
23.81 - 28.57
o-Diphenol
0.015 - 421
O2
0.00865
oxyresveratrol
-
pH 7.0, 25°C
0.268 - 4
p-coumaric acid
0.001 - 130
p-Cresol
0.06 - 0.8
p-tyrosol
0.33 - 12.5
phenol
0.64 - 1.4
phloretic acid
0.07 - 189
protocatechuic acid
0.15 - 2.87
Protocatechuic aldehyde
0.4 - 9.3
pyrocatechol
0.11 - 8
pyrogallate
0.3 - 3000
pyrogallol
79
quinol
-
-
0.46
resorcinol
-
pH 7.0, 25°C
1.2
tert-butylcathechol
-
-
0.54
trans-cinnamic acid
-
pH 3.5, 25°C
0.0077 - 9.53
tyramine
3
tyrosine
-
-
additional information
additional information
-