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1.14.16.1: phenylalanine 4-monooxygenase

This is an abbreviated version!
For detailed information about phenylalanine 4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.1

Reaction

L-phenylalanine
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
L-tyrosine
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

cePAH, DicPAH, EC 1.14.3.1, EC 1.99.1.2, HPAH, L-phenylalanine 4-hydroxylase, oxygenase, phenylalanine 4-mono-, P4H, PAH, PheH, phenylalaninase, phenylalanine 4-hydroxylase, phenylalanine hydroxylase, phenylalanine monooxygenase, PheOH, phhA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.1 phenylalanine 4-monooxygenase

Cofactor

Cofactor on EC 1.14.16.1 - phenylalanine 4-monooxygenase

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(6R)-5,6,7,8-tetrahydro-L-monapterin
-
7% of the activity with tetrahydrobiopterin
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
(7R)-tetrahydrobiopterin
8fold lower affinity and activity compared with 6(R)BH4
(7S)-tetrahydrobiopterin
8fold lower affinity and activity compared with 6(R)BH4
5,6,7,8-tetrahydro-L-biopterin
5,6,7,8-tetrahydrobiopterin
-
-
6,7-dimethyl-5,6,7,8-tetrahydrobiopterin
-
6,7-dimethyltetrahydropterin
-
17% of the activity with tetrahydrobiopterin
6-methyl-tetrahydrobiopterin
6-methyltetrahydrobiopterin
-
-
dihydrobiopterin
-
-
L-threo-neopterin
-
-
tetrahydrobiopterin
tetrahydrofolate
additional information
-